Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo
Alzheimer’s disease (AD) is a neurodegenerative disease. Due to its complex pathological mechanism, its etiology is not yet clear. As one of the main pathological markers of AD, amyloid-β (Aβ) plays an important role in the development of AD. The deposition of Aβ is not only related to the degenerat...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/11/990 |
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| author | Zhen-Yu Zhang Ze-Jun Li Ying-Hao Tang Liang Xu De-Teng Zhang Tian-Yi Qin Ya-Long Wang |
| author_facet | Zhen-Yu Zhang Ze-Jun Li Ying-Hao Tang Liang Xu De-Teng Zhang Tian-Yi Qin Ya-Long Wang |
| author_sort | Zhen-Yu Zhang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a neurodegenerative disease. Due to its complex pathological mechanism, its etiology is not yet clear. As one of the main pathological markers of AD, amyloid-β (Aβ) plays an important role in the development of AD. The deposition of Aβ is not only related to the degeneration of neurons, but also can activate a series of pathological events, including the activation of astrocytes and microglia, the breakdown of the blood–brain barrier, and the change in microcirculation, which is the main cause of brain lesions and death in AD patients. Therefore, the development of efficient and reliable Aβ-specific probes is crucial for the early diagnosis and treatment of AD. This paper focuses on reviewing the application of small-molecule fluorescent probes in Aβ imaging in vivo in recent years. These probes efficiently map the presence of Aβ in vivo, providing a pathway for the early diagnosis of AD and providing enlightenment for the design of Aβ-specific probes in the future. |
| first_indexed | 2024-03-09T16:58:53Z |
| format | Article |
| id | doaj.art-b8691425d8d44b44a1df54917dcd64c2 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T16:58:53Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-b8691425d8d44b44a1df54917dcd64c22023-11-24T14:32:28ZengMDPI AGBiosensors2079-63742023-11-01131199010.3390/bios13110990Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In VivoZhen-Yu Zhang0Ze-Jun Li1Ying-Hao Tang2Liang Xu3De-Teng Zhang4Tian-Yi Qin5Ya-Long Wang6State Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, ChinaInstitute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao 266071, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, ChinaState Key Laboratory of Digital Medical Engineering, School of Biomedical Engineering, Hainan University, Haikou 570228, ChinaAlzheimer’s disease (AD) is a neurodegenerative disease. Due to its complex pathological mechanism, its etiology is not yet clear. As one of the main pathological markers of AD, amyloid-β (Aβ) plays an important role in the development of AD. The deposition of Aβ is not only related to the degeneration of neurons, but also can activate a series of pathological events, including the activation of astrocytes and microglia, the breakdown of the blood–brain barrier, and the change in microcirculation, which is the main cause of brain lesions and death in AD patients. Therefore, the development of efficient and reliable Aβ-specific probes is crucial for the early diagnosis and treatment of AD. This paper focuses on reviewing the application of small-molecule fluorescent probes in Aβ imaging in vivo in recent years. These probes efficiently map the presence of Aβ in vivo, providing a pathway for the early diagnosis of AD and providing enlightenment for the design of Aβ-specific probes in the future.https://www.mdpi.com/2079-6374/13/11/990amyloid-β (Aβ)Alzheimer’s disease (AD)fluorescent probebioimaging |
| spellingShingle | Zhen-Yu Zhang Ze-Jun Li Ying-Hao Tang Liang Xu De-Teng Zhang Tian-Yi Qin Ya-Long Wang Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo Biosensors amyloid-β (Aβ) Alzheimer’s disease (AD) fluorescent probe bioimaging |
| title | Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo |
| title_full | Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo |
| title_fullStr | Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo |
| title_full_unstemmed | Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo |
| title_short | Recent Research Progress in Fluorescent Probes for Detection of Amyloid-β In Vivo |
| title_sort | recent research progress in fluorescent probes for detection of amyloid β in vivo |
| topic | amyloid-β (Aβ) Alzheimer’s disease (AD) fluorescent probe bioimaging |
| url | https://www.mdpi.com/2079-6374/13/11/990 |
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