Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma

Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma

Abstract Background Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insulinoma-associated 2 gene (INSM2) could regulate lipid metabolism in neur...

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Bibliographic Details
Main Authors: Haibo Cao, Ran Zhuo, Zimu Zhang, Jianwei Wang, Yanfang Tao, Randong Yang, Xinyi Guo, Yanling Chen, Siqi Jia, Ye Yao, Pengcheng Yang, Juanjuan Yu, Wanyan Jiao, Xiaolu Li, Fang Fang, Yi Xie, Gen Li, Di Wu, Hairong Wang, Chenxi Feng, Yunyun Xu, Zhiheng Li, Jian Pan, Jian Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cell & Bioscience
Subjects:
Super-enhancer
INSM2
Lipid metabolism
Neuroblastoma
mTOR
SREBP1
Online Access:https://doi.org/10.1186/s13578-022-00895-3

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