Metabolites Associated with Memory and Gait: A Systematic Review
We recently found that dual decline in memory and gait speed was consistently associated with an increased risk of dementia compared to decline in memory or gait only or no decline across six aging cohorts. The mechanisms underlying this relationship are unknown. We hypothesize that individuals who...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/4/356 |
| _version_ | 1797410045522083840 |
|---|---|
| author | Qu Tian Brendan A. Mitchell Abigail E. Corkum Ruin Moaddel Luigi Ferrucci |
| author_facet | Qu Tian Brendan A. Mitchell Abigail E. Corkum Ruin Moaddel Luigi Ferrucci |
| author_sort | Qu Tian |
| collection | DOAJ |
| description | We recently found that dual decline in memory and gait speed was consistently associated with an increased risk of dementia compared to decline in memory or gait only or no decline across six aging cohorts. The mechanisms underlying this relationship are unknown. We hypothesize that individuals who experience dual decline may have specific pathophysiological pathways to dementia which can be indicated by specific metabolomic signatures. Here, we summarize blood-based metabolites that are associated with memory and gait from existing literature and discuss their relevant pathways. A total of 39 eligible studies were included in this systematic review. Metabolites that were associated with memory and gait belonged to five shared classes: sphingolipids, fatty acids, phosphatidylcholines, amino acids, and biogenic amines. The sphingolipid metabolism pathway was found to be enriched in both memory and gait impairments. Existing data may suggest that metabolites from sphingolipids and the sphingolipid metabolism pathway are important for both memory and gait impairments. Future studies using empirical data across multiple cohorts are warranted to identify metabolomic signatures of dual decline in memory and gait and to further understand its relationship with future dementia risk. |
| first_indexed | 2024-03-09T04:24:11Z |
| format | Article |
| id | doaj.art-b86a52dda2964532892d92f3c05890ea |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T04:24:11Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-b86a52dda2964532892d92f3c05890ea2023-12-03T13:43:08ZengMDPI AGMetabolites2218-19892022-04-0112435610.3390/metabo12040356Metabolites Associated with Memory and Gait: A Systematic ReviewQu Tian0Brendan A. Mitchell1Abigail E. Corkum2Ruin Moaddel3Luigi Ferrucci4Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USALongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USALongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USALaboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USALongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21225, USAWe recently found that dual decline in memory and gait speed was consistently associated with an increased risk of dementia compared to decline in memory or gait only or no decline across six aging cohorts. The mechanisms underlying this relationship are unknown. We hypothesize that individuals who experience dual decline may have specific pathophysiological pathways to dementia which can be indicated by specific metabolomic signatures. Here, we summarize blood-based metabolites that are associated with memory and gait from existing literature and discuss their relevant pathways. A total of 39 eligible studies were included in this systematic review. Metabolites that were associated with memory and gait belonged to five shared classes: sphingolipids, fatty acids, phosphatidylcholines, amino acids, and biogenic amines. The sphingolipid metabolism pathway was found to be enriched in both memory and gait impairments. Existing data may suggest that metabolites from sphingolipids and the sphingolipid metabolism pathway are important for both memory and gait impairments. Future studies using empirical data across multiple cohorts are warranted to identify metabolomic signatures of dual decline in memory and gait and to further understand its relationship with future dementia risk.https://www.mdpi.com/2218-1989/12/4/356metabolomicsmemorygaitdementia |
| spellingShingle | Qu Tian Brendan A. Mitchell Abigail E. Corkum Ruin Moaddel Luigi Ferrucci Metabolites Associated with Memory and Gait: A Systematic Review Metabolites metabolomics memory gait dementia |
| title | Metabolites Associated with Memory and Gait: A Systematic Review |
| title_full | Metabolites Associated with Memory and Gait: A Systematic Review |
| title_fullStr | Metabolites Associated with Memory and Gait: A Systematic Review |
| title_full_unstemmed | Metabolites Associated with Memory and Gait: A Systematic Review |
| title_short | Metabolites Associated with Memory and Gait: A Systematic Review |
| title_sort | metabolites associated with memory and gait a systematic review |
| topic | metabolomics memory gait dementia |
| url | https://www.mdpi.com/2218-1989/12/4/356 |
| work_keys_str_mv | AT qutian metabolitesassociatedwithmemoryandgaitasystematicreview AT brendanamitchell metabolitesassociatedwithmemoryandgaitasystematicreview AT abigailecorkum metabolitesassociatedwithmemoryandgaitasystematicreview AT ruinmoaddel metabolitesassociatedwithmemoryandgaitasystematicreview AT luigiferrucci metabolitesassociatedwithmemoryandgaitasystematicreview |