Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system
Dynamin-related protein 1 (Drp1) is a member of the dynamin family of large GTPase, which cycles between the cytosol and the mitochondrial outer membrane, and mediates mitochondrial fission. Using microarray analysis of gene expression in the livers of wild-type and Drp1 knockout mice, we have previ...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-12-01
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| Series: | Genomics Data |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213596015001658 |
| _version_ | 1819116433148215296 |
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| author | Lixiang Wang Masatoshi Nomura |
| author_facet | Lixiang Wang Masatoshi Nomura |
| author_sort | Lixiang Wang |
| collection | DOAJ |
| description | Dynamin-related protein 1 (Drp1) is a member of the dynamin family of large GTPase, which cycles between the cytosol and the mitochondrial outer membrane, and mediates mitochondrial fission. Using microarray analysis of gene expression in the livers of wild-type and Drp1 knockout mice, we have previously identified that endoplasmic reticulum (ER) stress marker genes are significantly increased by the absence of Drp1 [1]. Here, we provide methodological and analytical details of the microarray data, which have been deposited in the Gene Expression Omnibus as data set GSE64222. We have performed further gene ontology analysis of the data and found the differential expression of a subset of genes that are involved in the immune response in the livers of Drp1 knockout mice versus wild-type controls. |
| first_indexed | 2024-12-22T05:17:00Z |
| format | Article |
| id | doaj.art-b86aae8fc2464103898e1a61d3f769b1 |
| institution | Directory Open Access Journal |
| issn | 2213-5960 |
| language | English |
| last_indexed | 2024-12-22T05:17:00Z |
| publishDate | 2015-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genomics Data |
| spelling | doaj.art-b86aae8fc2464103898e1a61d3f769b12022-12-21T18:37:50ZengElsevierGenomics Data2213-59602015-12-016C273010.1016/j.gdata.2015.07.021Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune systemLixiang WangMasatoshi NomuraDynamin-related protein 1 (Drp1) is a member of the dynamin family of large GTPase, which cycles between the cytosol and the mitochondrial outer membrane, and mediates mitochondrial fission. Using microarray analysis of gene expression in the livers of wild-type and Drp1 knockout mice, we have previously identified that endoplasmic reticulum (ER) stress marker genes are significantly increased by the absence of Drp1 [1]. Here, we provide methodological and analytical details of the microarray data, which have been deposited in the Gene Expression Omnibus as data set GSE64222. We have performed further gene ontology analysis of the data and found the differential expression of a subset of genes that are involved in the immune response in the livers of Drp1 knockout mice versus wild-type controls.http://www.sciencedirect.com/science/article/pii/S2213596015001658Dynamin-related protein 1Mitochondrial fissionImmune responseMicroarrays |
| spellingShingle | Lixiang Wang Masatoshi Nomura Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system Genomics Data Dynamin-related protein 1 Mitochondrial fission Immune response Microarrays |
| title | Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system |
| title_full | Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system |
| title_fullStr | Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system |
| title_full_unstemmed | Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system |
| title_short | Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system |
| title_sort | loss of drp1 in the liver leads to an alteration in expression of the genes involved in the immune system |
| topic | Dynamin-related protein 1 Mitochondrial fission Immune response Microarrays |
| url | http://www.sciencedirect.com/science/article/pii/S2213596015001658 |
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