A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan
The envelope of Gram-negative bacteria is critical for survival across a wide range of environmental conditions. The inner membrane, the periplasm and the outer membrane form a complex compartment, home to many essential processes. Hence, constant monitoring by envelope stress response systems ensur...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2019.00380/full |
| _version_ | 1818115613236658176 |
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| author | Antoine Delhaye Antoine Delhaye Jean-François Collet Jean-François Collet Géraldine Laloux |
| author_facet | Antoine Delhaye Antoine Delhaye Jean-François Collet Jean-François Collet Géraldine Laloux |
| author_sort | Antoine Delhaye |
| collection | DOAJ |
| description | The envelope of Gram-negative bacteria is critical for survival across a wide range of environmental conditions. The inner membrane, the periplasm and the outer membrane form a complex compartment, home to many essential processes. Hence, constant monitoring by envelope stress response systems ensure correct biogenesis of the envelope and maintain its homeostasis. Inside the periplasm, the cell wall, made of peptidoglycan, has been under the spotlight for its critical role in bacterial growth as well as being the target of many antibiotics. While much research is centered around understanding the role of the many enzymes involved in synthesizing the cell wall, much less is known about how the cell can detect perturbations of this assembly process, and how it is regulated during stress. In this review, we explore the current knowledge of cell wall defects sensing by stress response systems, mainly in the model bacterium Escherichia coli. We also discuss how these systems can respond to cell wall perturbations to increase fitness, and what implications this has on cell wall regulation. |
| first_indexed | 2024-12-11T04:09:24Z |
| format | Article |
| id | doaj.art-b86af58c5d664fa88880cba737da903f |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-11T04:09:24Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b86af58c5d664fa88880cba737da903f2022-12-22T01:21:26ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882019-11-01910.3389/fcimb.2019.00380483028A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to PeptidoglycanAntoine Delhaye0Antoine Delhaye1Jean-François Collet2Jean-François Collet3Géraldine Laloux4de Duve Institute, UCLouvain, Brussels, BelgiumWalloon Excellence in Life Sciences and Biotechnology (WELBIO), Brussels, Belgiumde Duve Institute, UCLouvain, Brussels, BelgiumWalloon Excellence in Life Sciences and Biotechnology (WELBIO), Brussels, Belgiumde Duve Institute, UCLouvain, Brussels, BelgiumThe envelope of Gram-negative bacteria is critical for survival across a wide range of environmental conditions. The inner membrane, the periplasm and the outer membrane form a complex compartment, home to many essential processes. Hence, constant monitoring by envelope stress response systems ensure correct biogenesis of the envelope and maintain its homeostasis. Inside the periplasm, the cell wall, made of peptidoglycan, has been under the spotlight for its critical role in bacterial growth as well as being the target of many antibiotics. While much research is centered around understanding the role of the many enzymes involved in synthesizing the cell wall, much less is known about how the cell can detect perturbations of this assembly process, and how it is regulated during stress. In this review, we explore the current knowledge of cell wall defects sensing by stress response systems, mainly in the model bacterium Escherichia coli. We also discuss how these systems can respond to cell wall perturbations to increase fitness, and what implications this has on cell wall regulation.https://www.frontiersin.org/article/10.3389/fcimb.2019.00380/fullstress responseESRScell wallCpxRCSPsp |
| spellingShingle | Antoine Delhaye Antoine Delhaye Jean-François Collet Jean-François Collet Géraldine Laloux A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan Frontiers in Cellular and Infection Microbiology stress response ESRS cell wall Cpx RCS Psp |
| title | A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan |
| title_full | A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan |
| title_fullStr | A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan |
| title_full_unstemmed | A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan |
| title_short | A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan |
| title_sort | fly on the wall how stress response systems can sense and respond to damage to peptidoglycan |
| topic | stress response ESRS cell wall Cpx RCS Psp |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2019.00380/full |
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