A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone
Herein, a paper-based electrochemical sensor based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COF<sub>TFPB−DHzDS</sub>) was successfully grown on the surface of amino-functional re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/12/10/904 |
| _version_ | 1797474802156437504 |
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| author | Rongfang Chen Xia Peng Yonghai Song Yan Du |
| author_facet | Rongfang Chen Xia Peng Yonghai Song Yan Du |
| author_sort | Rongfang Chen |
| collection | DOAJ |
| description | Herein, a paper-based electrochemical sensor based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COF<sub>TFPB−DHzDS</sub>) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH<sub>2</sub>) to avoid serious self-aggregation, which was further loaded with platinum nanoparticles (PtNPs) with high catalytic activity as nanozyme to obtain PtNP/COF<sub>TFPB−DHzDS</sub>@rGO nanocomposites. The morphology of PtNP/COF<sub>TFPB−DHzDS</sub>@rGO nanocomposites was characterized, and the results showed that the smooth rGO surface became extremely rough after the modification of COF<sub>TFPB−DHzDS</sub>. Meanwhile, ultra-small PtNPs with sizes of around 1 nm were precisely anchored on COF<sub>TFPB−DHzDS</sub> to maintain their excellent catalytic activity. The conventional electrodes were used to detect furazolidone and showed a detection limit as low as 5 nM and a linear range from 15 nM to 110 μM. In contrast, the detection limit for the paper-based electrode was 0.23 μM, and the linear range was 0.69–110 μM. The results showed that the paper-based electrode can be used to detect furazolidone. This sensor is a potential candidate for the detection of furazolidone residue in human serum and fish samples. |
| first_indexed | 2024-03-09T20:35:16Z |
| format | Article |
| id | doaj.art-b86bdbe2c1f84a4e8b836d31d97f0ec2 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T20:35:16Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-b86bdbe2c1f84a4e8b836d31d97f0ec22023-11-23T23:12:33ZengMDPI AGBiosensors2079-63742022-10-01121090410.3390/bios12100904A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of FurazolidoneRongfang Chen0Xia Peng1Yonghai Song2Yan Du3National Engineering Research Center for Carbohydrate Synthesis, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaNational Engineering Research Center for Carbohydrate Synthesis, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaNational Engineering Research Center for Carbohydrate Synthesis, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaNational Engineering Research Center for Carbohydrate Synthesis, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, ChinaHerein, a paper-based electrochemical sensor based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COF<sub>TFPB−DHzDS</sub>) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH<sub>2</sub>) to avoid serious self-aggregation, which was further loaded with platinum nanoparticles (PtNPs) with high catalytic activity as nanozyme to obtain PtNP/COF<sub>TFPB−DHzDS</sub>@rGO nanocomposites. The morphology of PtNP/COF<sub>TFPB−DHzDS</sub>@rGO nanocomposites was characterized, and the results showed that the smooth rGO surface became extremely rough after the modification of COF<sub>TFPB−DHzDS</sub>. Meanwhile, ultra-small PtNPs with sizes of around 1 nm were precisely anchored on COF<sub>TFPB−DHzDS</sub> to maintain their excellent catalytic activity. The conventional electrodes were used to detect furazolidone and showed a detection limit as low as 5 nM and a linear range from 15 nM to 110 μM. In contrast, the detection limit for the paper-based electrode was 0.23 μM, and the linear range was 0.69–110 μM. The results showed that the paper-based electrode can be used to detect furazolidone. This sensor is a potential candidate for the detection of furazolidone residue in human serum and fish samples.https://www.mdpi.com/2079-6374/12/10/904paper-based electrodereduced graphene oxidecovalent organic frameworkfurazolidoneelectrochemical sensor |
| spellingShingle | Rongfang Chen Xia Peng Yonghai Song Yan Du A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone Biosensors paper-based electrode reduced graphene oxide covalent organic framework furazolidone electrochemical sensor |
| title | A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone |
| title_full | A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone |
| title_fullStr | A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone |
| title_full_unstemmed | A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone |
| title_short | A Paper-Based Electrochemical Sensor Based on PtNP/COF<sub>TFPB−DHzDS</sub>@rGO for Sensitive Detection of Furazolidone |
| title_sort | paper based electrochemical sensor based on ptnp cof sub tfpb dhzds sub rgo for sensitive detection of furazolidone |
| topic | paper-based electrode reduced graphene oxide covalent organic framework furazolidone electrochemical sensor |
| url | https://www.mdpi.com/2079-6374/12/10/904 |
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