Gamma reactivation using the spongy effect of KLF1-binding site sequence: an approach in gene therapy for beta-thalassemia

Gamma reactivation using the spongy effect of KLF1-binding site sequence: an approach in gene therapy for beta-thalassemia

Objective(s): β-thalassemia is one of the most common genetic disorders in the world. As one of the promising treatment strategies, fetal hemoglobin (Hb F) can be induced. The present study was an attempt to reactivate the γ-globin gene by introducing a gene construct containing KLF1 binding sites t...

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Bibliographic Details
Main Authors:	Nasrin Heydari, Laleh Shariati, Hossein Khanahmad, Zahra Hejazi, Mansoureh Shahbazi, Mansoor Salehi
Format:	Article
Language:	English
Published:	Mashhad University of Medical Sciences 2016-10-01
Series:	Iranian Journal of Basic Medical Sciences
Subjects:	Hb F induction KLF1 gene β-switching β-thalassemia γ-globin
Online Access:	http://ijbms.mums.ac.ir/article_7731_bf7a1207e8bbca99d681d259846d4e30.pdf

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