Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018
Abstract Background Serum vitamin D deficiency is common in the patients with cardiovascular disease (CVD), but the association between serum vitamin D levels and risk of all-cause mortality in patients with CVD is controversial. Objective This study aimed to understand better the association betwee...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-023-03257-0 |
| _version_ | 1827952892073476096 |
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| author | Ben Hu Jian Chen Yihang Shi Linlin Hou |
| author_facet | Ben Hu Jian Chen Yihang Shi Linlin Hou |
| author_sort | Ben Hu |
| collection | DOAJ |
| description | Abstract Background Serum vitamin D deficiency is common in the patients with cardiovascular disease (CVD), but the association between serum vitamin D levels and risk of all-cause mortality in patients with CVD is controversial. Objective This study aimed to understand better the association between serum 25(OH)D status and risk of all-cause mortality in patients with prior CVD. Method We conducted a cohort study using data from the National Health and Nutrition Examination Survey from 2007 to 2018 to investigate the association between serum 25(OH)D and the risk of all-cause mortality using multivariate Cox regression models, with further subgroup analyses and interactions smooth curve fitting to address possible nonlinearities. Result A total of 3220 participants with prior CVD were included in this study, with a total of 930 deaths over a median follow-up of 5.52 years, with multivariable-adjusted serum vitamin D levels after natural log transformation (4.31–4.5 ) as a reference in COX regression, and corrected HRs and 95% CIs of 1.81 (1.31, 2.50), 1.34 (1.07, 1.66), 1.28 (1.05, 1.56),1.00 (reference), 1.10 (0.89, 1.37) for all-cause mortality, respectively. Results remained robust in the stratified analysis of interactions, but a L-shaped relationship was detected. We identified an inflection point of 4.5 after multivariate adjustment through a two-stage linear regression model and recursive algorithm. Conclusion Our findings demonstrate that increasing serum 25(OH)D levels may have a L-shaped relationship with risk of all-cause mortality and that increases in serum 25(OH)D levels do not continue to reduce the risk of all-cause mortality. |
| first_indexed | 2024-04-09T14:05:47Z |
| format | Article |
| id | doaj.art-b86c8544517b455b9c4da54ffd64d28c |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-09T14:05:47Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-b86c8544517b455b9c4da54ffd64d28c2023-05-07T11:04:49ZengBMCBMC Cardiovascular Disorders1471-22612023-05-0123111110.1186/s12872-023-03257-0Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018Ben Hu0Jian Chen1Yihang Shi2Linlin Hou3Department of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical UniversityDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical UniversityDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical UniversityDepartment of Cardiology, The Second People’s Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical UniversityAbstract Background Serum vitamin D deficiency is common in the patients with cardiovascular disease (CVD), but the association between serum vitamin D levels and risk of all-cause mortality in patients with CVD is controversial. Objective This study aimed to understand better the association between serum 25(OH)D status and risk of all-cause mortality in patients with prior CVD. Method We conducted a cohort study using data from the National Health and Nutrition Examination Survey from 2007 to 2018 to investigate the association between serum 25(OH)D and the risk of all-cause mortality using multivariate Cox regression models, with further subgroup analyses and interactions smooth curve fitting to address possible nonlinearities. Result A total of 3220 participants with prior CVD were included in this study, with a total of 930 deaths over a median follow-up of 5.52 years, with multivariable-adjusted serum vitamin D levels after natural log transformation (4.31–4.5 ) as a reference in COX regression, and corrected HRs and 95% CIs of 1.81 (1.31, 2.50), 1.34 (1.07, 1.66), 1.28 (1.05, 1.56),1.00 (reference), 1.10 (0.89, 1.37) for all-cause mortality, respectively. Results remained robust in the stratified analysis of interactions, but a L-shaped relationship was detected. We identified an inflection point of 4.5 after multivariate adjustment through a two-stage linear regression model and recursive algorithm. Conclusion Our findings demonstrate that increasing serum 25(OH)D levels may have a L-shaped relationship with risk of all-cause mortality and that increases in serum 25(OH)D levels do not continue to reduce the risk of all-cause mortality.https://doi.org/10.1186/s12872-023-03257-0Vitamin DCohort studyMortalityCardiovascular diseaseNHANES |
| spellingShingle | Ben Hu Jian Chen Yihang Shi Linlin Hou Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018 BMC Cardiovascular Disorders Vitamin D Cohort study Mortality Cardiovascular disease NHANES |
| title | Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018 |
| title_full | Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018 |
| title_fullStr | Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018 |
| title_full_unstemmed | Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018 |
| title_short | Association between serum 25(OH)D and risk of all-cause mortality in adults with prior cardiovascular disease: a cohort study from NHANES 2007–2018 |
| title_sort | association between serum 25 oh d and risk of all cause mortality in adults with prior cardiovascular disease a cohort study from nhanes 2007 2018 |
| topic | Vitamin D Cohort study Mortality Cardiovascular disease NHANES |
| url | https://doi.org/10.1186/s12872-023-03257-0 |
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