Selective inhibition of human translation termination by a drug-like compound
The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1)...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18765-2 |
| _version_ | 1818692113519345664 |
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| author | Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate |
| author_facet | Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate |
| author_sort | Wenfei Li |
| collection | DOAJ |
| description | The drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1). |
| first_indexed | 2024-12-17T12:52:38Z |
| format | Article |
| id | doaj.art-b86e399a4ec045d89db7d9e3ea9c2b22 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:52:38Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b86e399a4ec045d89db7d9e3ea9c2b222022-12-21T21:47:33ZengNature PortfolioNature Communications2041-17232020-10-011111910.1038/s41467-020-18765-2Selective inhibition of human translation termination by a drug-like compoundWenfei Li0Stacey Tsai-Lan Chang1Fred. R. Ward2Jamie H. D. Cate3Department of Molecular & Cell Biology, University of CaliforniaDepartment of Molecular & Cell Biology, University of CaliforniaDepartment of Molecular & Cell Biology, University of CaliforniaDepartment of Molecular & Cell Biology, University of CaliforniaThe drug-like compound PF846 and its derivatives inhibit the translation of specific mRNAs by the human ribosome. Here the authors show how PF846 arrests translation at the stop codon by slowing hydrolysis of the protein nascent chain at the ribosome P-site tRNA by eukaryotic release factor 1 (eRF1).https://doi.org/10.1038/s41467-020-18765-2 |
| spellingShingle | Wenfei Li Stacey Tsai-Lan Chang Fred. R. Ward Jamie H. D. Cate Selective inhibition of human translation termination by a drug-like compound Nature Communications |
| title | Selective inhibition of human translation termination by a drug-like compound |
| title_full | Selective inhibition of human translation termination by a drug-like compound |
| title_fullStr | Selective inhibition of human translation termination by a drug-like compound |
| title_full_unstemmed | Selective inhibition of human translation termination by a drug-like compound |
| title_short | Selective inhibition of human translation termination by a drug-like compound |
| title_sort | selective inhibition of human translation termination by a drug like compound |
| url | https://doi.org/10.1038/s41467-020-18765-2 |
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