Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial
Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing <i>Pinus massoniana</i> bark extr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/8/1560 |
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| author | Jessica J. A. Ferguson Christopher Oldmeadow David Bentley Manohar L. Garg |
| author_facet | Jessica J. A. Ferguson Christopher Oldmeadow David Bentley Manohar L. Garg |
| author_sort | Jessica J. A. Ferguson |
| collection | DOAJ |
| description | Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing <i>Pinus massoniana</i> bark extract (PMBE) in healthy older adults. In a double-blinded, placebo-controlled clinical trial, participants were randomised (in a 1:1 ratio) to receive a 50 mL/day dietary supplement containing placebo (0 mg PMBE) or PMBE (1322 mg PMBE) for 12 weeks. The primary outcome was fasting plasma malondialdehyde (MDA) concentrations and secondary outcomes were plasma inflammatory markers. MDA concentrations significantly reduced following PMBE for 6 weeks (−1.19 nmol/mL, 95%CI −1.62, −0.75, <i>p</i> < 0.001) and 12 weeks (−1.35 nmol/mL, 95%CI −1.74, −0.96, <i>p</i> < 0.001) compared to baseline. MDA did not significantly change after the placebo. MDA levels at 6 and 12 weeks were significantly lower following PMBE compared to placebo (<i>p</i> < 0.001). At 12 weeks in the PMBE group, fibrinogen concentrations significantly reduced (−0.25 g/L, 95%CI −0.39, −0.11; <i>p</i> < 0.0001) and interleukin-6 significantly increased compared to placebo (0.30 pg/mL, 95%CI 0.02, 0.59; <i>p</i> < 0.05). PMBE in a polyphenol-rich dietary supplement reduced oxidative stress in healthy older adults. Further studies are warranted to investigate the antioxidant capacity of PMBE in conditions with heightened oxidative stress, such as osteoarthritis, hypertension, type 2 diabetes, or other lifestyle related diseases. |
| first_indexed | 2024-03-09T11:58:53Z |
| format | Article |
| id | doaj.art-b870075fb91a41dd9d9c8c0d2f678444 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:58:53Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b870075fb91a41dd9d9c8c0d2f6784442023-11-30T23:06:21ZengMDPI AGAntioxidants2076-39212022-08-01118156010.3390/antiox11081560Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled TrialJessica J. A. Ferguson0Christopher Oldmeadow1David Bentley2Manohar L. Garg3Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, AustraliaClinical Research Design, Information Technology and Statistical Support Unit, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW 2308, AustraliaSchool of Life and Environmental Science, University of Newcastle, Ourimbah, NSW 2258, AustraliaNutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, AustraliaOxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing <i>Pinus massoniana</i> bark extract (PMBE) in healthy older adults. In a double-blinded, placebo-controlled clinical trial, participants were randomised (in a 1:1 ratio) to receive a 50 mL/day dietary supplement containing placebo (0 mg PMBE) or PMBE (1322 mg PMBE) for 12 weeks. The primary outcome was fasting plasma malondialdehyde (MDA) concentrations and secondary outcomes were plasma inflammatory markers. MDA concentrations significantly reduced following PMBE for 6 weeks (−1.19 nmol/mL, 95%CI −1.62, −0.75, <i>p</i> < 0.001) and 12 weeks (−1.35 nmol/mL, 95%CI −1.74, −0.96, <i>p</i> < 0.001) compared to baseline. MDA did not significantly change after the placebo. MDA levels at 6 and 12 weeks were significantly lower following PMBE compared to placebo (<i>p</i> < 0.001). At 12 weeks in the PMBE group, fibrinogen concentrations significantly reduced (−0.25 g/L, 95%CI −0.39, −0.11; <i>p</i> < 0.0001) and interleukin-6 significantly increased compared to placebo (0.30 pg/mL, 95%CI 0.02, 0.59; <i>p</i> < 0.05). PMBE in a polyphenol-rich dietary supplement reduced oxidative stress in healthy older adults. Further studies are warranted to investigate the antioxidant capacity of PMBE in conditions with heightened oxidative stress, such as osteoarthritis, hypertension, type 2 diabetes, or other lifestyle related diseases.https://www.mdpi.com/2076-3921/11/8/1560ageingpine barkproanthocyanidinsantioxidantspolyphenolsoxidative stress |
| spellingShingle | Jessica J. A. Ferguson Christopher Oldmeadow David Bentley Manohar L. Garg Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial Antioxidants ageing pine bark proanthocyanidins antioxidants polyphenols oxidative stress |
| title | Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial |
| title_full | Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial |
| title_fullStr | Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial |
| title_full_unstemmed | Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial |
| title_short | Antioxidant Effects of a Polyphenol-Rich Dietary Supplement Incorporating <i>Pinus massoniana</i> Bark Extract in Healthy Older Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial |
| title_sort | antioxidant effects of a polyphenol rich dietary supplement incorporating i pinus massoniana i bark extract in healthy older adults a two arm parallel group randomized placebo controlled trial |
| topic | ageing pine bark proanthocyanidins antioxidants polyphenols oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/8/1560 |
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