The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study
Introduction: Thyroid disorders, particularly hypothyroidism, are the most common thyroid disorders in India, affecting one in ten adults. Autoimmunity may play a significant role in the progression of hyperlipidaemia, which is one of the recurrent issues associated with thyroid disorders. Altho...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2023-12-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://www.jcdr.net/articles/PDF/18849/66163_CE[Ra1]_F(KR)_QC&Ref(SD_SL)_PF1(AG_KM)_PFA(OM)_PB(AG_KM)_PN(KM).pdf |
Summary: | Introduction: Thyroid disorders, particularly hypothyroidism,
are the most common thyroid disorders in India, affecting one
in ten adults. Autoimmunity may play a significant role in the
progression of hyperlipidaemia, which is one of the recurrent
issues associated with thyroid disorders. Although serum lipids
have been proven to control immunological and inflammatory
responses, little is known about their relationship to thyroid
autoimmunity.
Aim: To investigate the association between Thyroid Peroxidase
Antibody (anti-TPO) and serum lipid parameters among patients
diagnosed with hypothyroidism.
Materials and Methods: A hospital-based cross-sectional
study was conducted at Parul Sevashram Hospital in Vadodara,
Gujarat from November 2022 to May 2023. A total of 103
patients with hypothyroidism were included in the study. All
patients underwent estimation of thyroid function parameters
such as triiodothyronine (T3), thyroxine (T4), and ThyroidStimulating Hormone (TSH), as well as anti-TPO levels and
selected lipid profile parameters such as Total Cholesterol (TC),
Triglycerides (TG), High-Density Lipoproteins (HDL), and LowDensity Lipoproteins (LDL). The association between anti-TPO
and lipid levels was further analysed. Statistical analysis was
performed using the Chi-square test.
Results: Among the 103 hypothyroid patients, 83 (80.6%) were
females, while only 20 (19.4%) were males. Positive serum antiTPO antibodies were found in 79 (76.7%) patients, whereas
negative Anti-TPO cases accounted for 24 (23.3%). The total
serum cholesterol, with a mean of 226.88±37.44 mg/dL, and
serum LDL, with 145.31±34.60 mg/dL, were significantly
increased (p-value<0.01), whereas the serum TG with a mean
of 181.06±52.13 mg/dL, and serum HDL, with 44.61±7.87 mg/
dL, were found to be non significant (p-value>0.05).
Conclusion: Hypothyroid patients positive for anti-TPO
antibodies are at risk of experiencing disrupted lipid levels.
There was a significant association between positive anti-TPO
status and TC and LDL in the present study. |
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ISSN: | 2249-782X 0973-709X |