The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study
Introduction: Thyroid disorders, particularly hypothyroidism, are the most common thyroid disorders in India, affecting one in ten adults. Autoimmunity may play a significant role in the progression of hyperlipidaemia, which is one of the recurrent issues associated with thyroid disorders. Altho...
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JCDR Research and Publications Private Limited
2023-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/18849/66163_CE[Ra1]_F(KR)_QC&Ref(SD_SL)_PF1(AG_KM)_PFA(OM)_PB(AG_KM)_PN(KM).pdf |
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| author | Itisha Katha Nivedita Priya |
| author_facet | Itisha Katha Nivedita Priya |
| author_sort | Itisha Katha |
| collection | DOAJ |
| description | Introduction: Thyroid disorders, particularly hypothyroidism,
are the most common thyroid disorders in India, affecting one
in ten adults. Autoimmunity may play a significant role in the
progression of hyperlipidaemia, which is one of the recurrent
issues associated with thyroid disorders. Although serum lipids
have been proven to control immunological and inflammatory
responses, little is known about their relationship to thyroid
autoimmunity.
Aim: To investigate the association between Thyroid Peroxidase
Antibody (anti-TPO) and serum lipid parameters among patients
diagnosed with hypothyroidism.
Materials and Methods: A hospital-based cross-sectional
study was conducted at Parul Sevashram Hospital in Vadodara,
Gujarat from November 2022 to May 2023. A total of 103
patients with hypothyroidism were included in the study. All
patients underwent estimation of thyroid function parameters
such as triiodothyronine (T3), thyroxine (T4), and ThyroidStimulating Hormone (TSH), as well as anti-TPO levels and
selected lipid profile parameters such as Total Cholesterol (TC),
Triglycerides (TG), High-Density Lipoproteins (HDL), and LowDensity Lipoproteins (LDL). The association between anti-TPO
and lipid levels was further analysed. Statistical analysis was
performed using the Chi-square test.
Results: Among the 103 hypothyroid patients, 83 (80.6%) were
females, while only 20 (19.4%) were males. Positive serum antiTPO antibodies were found in 79 (76.7%) patients, whereas
negative Anti-TPO cases accounted for 24 (23.3%). The total
serum cholesterol, with a mean of 226.88±37.44 mg/dL, and
serum LDL, with 145.31±34.60 mg/dL, were significantly
increased (p-value<0.01), whereas the serum TG with a mean
of 181.06±52.13 mg/dL, and serum HDL, with 44.61±7.87 mg/
dL, were found to be non significant (p-value>0.05).
Conclusion: Hypothyroid patients positive for anti-TPO
antibodies are at risk of experiencing disrupted lipid levels.
There was a significant association between positive anti-TPO
status and TC and LDL in the present study. |
| first_indexed | 2024-03-08T19:23:47Z |
| format | Article |
| id | doaj.art-b873c786bff847f1ae109ebf7bcd8512 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-08T19:23:47Z |
| publishDate | 2023-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-b873c786bff847f1ae109ebf7bcd85122023-12-26T12:15:38ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-12-011712151810.7860/JCDR/2023/66163.18849The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional StudyItisha Katha0Nivedita Priya1Postgraduate Student, Parul Institute of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara, Gujarat, India.Assistant Professor, Parul Institute of Paramedical and Health Sciences, Faculty of Medicine, Parul University, Vadodara, Gujarat, India.Introduction: Thyroid disorders, particularly hypothyroidism, are the most common thyroid disorders in India, affecting one in ten adults. Autoimmunity may play a significant role in the progression of hyperlipidaemia, which is one of the recurrent issues associated with thyroid disorders. Although serum lipids have been proven to control immunological and inflammatory responses, little is known about their relationship to thyroid autoimmunity. Aim: To investigate the association between Thyroid Peroxidase Antibody (anti-TPO) and serum lipid parameters among patients diagnosed with hypothyroidism. Materials and Methods: A hospital-based cross-sectional study was conducted at Parul Sevashram Hospital in Vadodara, Gujarat from November 2022 to May 2023. A total of 103 patients with hypothyroidism were included in the study. All patients underwent estimation of thyroid function parameters such as triiodothyronine (T3), thyroxine (T4), and ThyroidStimulating Hormone (TSH), as well as anti-TPO levels and selected lipid profile parameters such as Total Cholesterol (TC), Triglycerides (TG), High-Density Lipoproteins (HDL), and LowDensity Lipoproteins (LDL). The association between anti-TPO and lipid levels was further analysed. Statistical analysis was performed using the Chi-square test. Results: Among the 103 hypothyroid patients, 83 (80.6%) were females, while only 20 (19.4%) were males. Positive serum antiTPO antibodies were found in 79 (76.7%) patients, whereas negative Anti-TPO cases accounted for 24 (23.3%). The total serum cholesterol, with a mean of 226.88±37.44 mg/dL, and serum LDL, with 145.31±34.60 mg/dL, were significantly increased (p-value<0.01), whereas the serum TG with a mean of 181.06±52.13 mg/dL, and serum HDL, with 44.61±7.87 mg/ dL, were found to be non significant (p-value>0.05). Conclusion: Hypothyroid patients positive for anti-TPO antibodies are at risk of experiencing disrupted lipid levels. There was a significant association between positive anti-TPO status and TC and LDL in the present study.https://www.jcdr.net/articles/PDF/18849/66163_CE[Ra1]_F(KR)_QC&Ref(SD_SL)_PF1(AG_KM)_PFA(OM)_PB(AG_KM)_PN(KM).pdfhypercholesterolaemiahyperlipidaemiaimmunological responsethyroid autoantibodiesthyroid-stimulating hormone |
| spellingShingle | Itisha Katha Nivedita Priya The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study Journal of Clinical and Diagnostic Research hypercholesterolaemia hyperlipidaemia immunological response thyroid autoantibodies thyroid-stimulating hormone |
| title | The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study |
| title_full | The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study |
| title_fullStr | The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study |
| title_full_unstemmed | The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study |
| title_short | The Association of Thyroid Autoimmunity and Lipid Profile in Hypothyroidism: A Cross-sectional Study |
| title_sort | association of thyroid autoimmunity and lipid profile in hypothyroidism a cross sectional study |
| topic | hypercholesterolaemia hyperlipidaemia immunological response thyroid autoantibodies thyroid-stimulating hormone |
| url | https://www.jcdr.net/articles/PDF/18849/66163_CE[Ra1]_F(KR)_QC&Ref(SD_SL)_PF1(AG_KM)_PFA(OM)_PB(AG_KM)_PN(KM).pdf |
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