Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats.
OBJECTIVES: Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that the pathophysiology of vas...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4175999?pdf=render |
| _version_ | 1811320842009706496 |
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| author | Erik N T P Bakker Gergely Groma Léon J A Spijkers Judith de Vos Angela van Weert Henk van Veen Vincent Everts Silvia M Arribas Ed VanBavel |
| author_facet | Erik N T P Bakker Gergely Groma Léon J A Spijkers Judith de Vos Angela van Weert Henk van Veen Vincent Everts Silvia M Arribas Ed VanBavel |
| author_sort | Erik N T P Bakker |
| collection | DOAJ |
| description | OBJECTIVES: Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that the pathophysiology of vascular remodeling in hypertension differs among rat sublines. METHODS AND RESULTS: We studied mesenteric resistance arteries of WKY and SHR from three different sources, at 6 weeks and 5 months of age. Sublines of WKY and SHR showed differences in blood pressure, body weight, vascular remodeling, endothelial function, and vessel ultrastructure. Common features in small mesenteric arteries from SHR were an increase in wall thickness, wall-to-lumen ratio, and internal elastic lamina thickness. CONCLUSIONS: Endothelial dysfunction, vascular stiffening, and inward remodeling of small mesenteric arteries are not common features of hypertension, but are subline-dependent. Differences in genetic background associate with different types of vascular remodeling in hypertensive rats. |
| first_indexed | 2024-04-13T13:06:47Z |
| format | Article |
| id | doaj.art-b8748ad080fb4f7488d53eb8ffd33476 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:06:47Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b8748ad080fb4f7488d53eb8ffd334762022-12-22T02:45:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10799810.1371/journal.pone.0107998Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats.Erik N T P BakkerGergely GromaLéon J A SpijkersJudith de VosAngela van WeertHenk van VeenVincent EvertsSilvia M ArribasEd VanBavelOBJECTIVES: Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that the pathophysiology of vascular remodeling in hypertension differs among rat sublines. METHODS AND RESULTS: We studied mesenteric resistance arteries of WKY and SHR from three different sources, at 6 weeks and 5 months of age. Sublines of WKY and SHR showed differences in blood pressure, body weight, vascular remodeling, endothelial function, and vessel ultrastructure. Common features in small mesenteric arteries from SHR were an increase in wall thickness, wall-to-lumen ratio, and internal elastic lamina thickness. CONCLUSIONS: Endothelial dysfunction, vascular stiffening, and inward remodeling of small mesenteric arteries are not common features of hypertension, but are subline-dependent. Differences in genetic background associate with different types of vascular remodeling in hypertensive rats.http://europepmc.org/articles/PMC4175999?pdf=render |
| spellingShingle | Erik N T P Bakker Gergely Groma Léon J A Spijkers Judith de Vos Angela van Weert Henk van Veen Vincent Everts Silvia M Arribas Ed VanBavel Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats. PLoS ONE |
| title | Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats. |
| title_full | Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats. |
| title_fullStr | Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats. |
| title_full_unstemmed | Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats. |
| title_short | Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats. |
| title_sort | heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats |
| url | http://europepmc.org/articles/PMC4175999?pdf=render |
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