Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers
This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dime...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.632753/full |
| _version_ | 1819295926250897408 |
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| author | Karen K. Gleason |
| author_facet | Karen K. Gleason |
| author_sort | Karen K. Gleason |
| collection | DOAJ |
| description | This review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release. |
| first_indexed | 2024-12-24T04:49:58Z |
| format | Article |
| id | doaj.art-b877b551d869411f92ca7f006d752536 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-24T04:49:58Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b877b551d869411f92ca7f006d7525362022-12-21T17:14:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-01-01910.3389/fbioe.2021.632753632753Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric NanolayersKaren K. GleasonThis review will focus on the controlled release of pharmaceuticals and other organic molecules utilizing polymeric nanolayers grown by initiated chemical vapor deposited (iCVD). The iCVD layers are able conform to the geometry of the underlying substrate, facilitating release from one- and two-dimensional nanostructures with high surface area. The reactors for iCVD film growth can be customized for specific substrate geometries and scaled to large overall dimensions. The absence of surface tension in vapor deposition processes allows the synthesis of pinhole-free layers, even for iCVD layers <10 nm thick. Such ultrathin layers also provide rapid transport of the drug across the polymeric layer. The mild conditions of the iCVD process avoid damage to the drug which is being encapsulated. Smart release is enabled by iCVD hydrogels which are responsive to pH, temperature, or light. Biodegradable iCVD layers have also be demonstrated for drug release.https://www.frontiersin.org/articles/10.3389/fbioe.2021.632753/fulldrug delivery systemsinitiated chemical vapor depositionthin filmsnanofibersconformal coatingsmart materials |
| spellingShingle | Karen K. Gleason Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers Frontiers in Bioengineering and Biotechnology drug delivery systems initiated chemical vapor deposition thin films nanofibers conformal coating smart materials |
| title | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_full | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_fullStr | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_full_unstemmed | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_short | Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers |
| title_sort | controlled release utilizing initiated chemical vapor deposited icvd of polymeric nanolayers |
| topic | drug delivery systems initiated chemical vapor deposition thin films nanofibers conformal coating smart materials |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.632753/full |
| work_keys_str_mv | AT karenkgleason controlledreleaseutilizinginitiatedchemicalvapordepositedicvdofpolymericnanolayers |