CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION
The subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2018-07-01
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| Series: | Acta Biomedica Scientifica |
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| Online Access: | https://www.actabiomedica.ru/jour/article/view/648 |
| _version_ | 1797237359703490560 |
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| author | G. N. Leonova |
| author_facet | G. N. Leonova |
| author_sort | G. N. Leonova |
| collection | DOAJ |
| description | The subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific antibodies in persons vaccinated against TBE.The aim of the present study is to show the differences in biological properties on the model of two strains of Far Eastern TBEV subtype belonging to different clusters and to substantiate the need for a personalized approach to the vaccine prophylaxis of tick-borne encephalitis.Results. Two strains of TBEV were used in the studies. On the basis of full genome sequencing the Dal’negorsk strain (FJ402886, GenBank) is referred to the typical representative of Sofjin-like, and Primorye-437 (JQ825162, GenBank) – to Oshima-like TBEV strains of the Far Eastern subtype.The experiment shows the levels of specific antibodies capable of neutralizing virulence strains of tick- borne encephalitis virus. Low antibody titers (1:100 and 1:400) can neutralize only a low dose of a non-virulent strain of tick-borne encephalitis virus. Reliable protection against the disease of people infected with virulent strains of the TBEV can provide only a high level of specific antibodies.Conclusion. If the level of specific antibodies of IgG is 1:400 or lower, the vaccination course should be continued, at a titer of antibodies above 1:400, revaccination can be postponed subject to annual monitoring of specific immunity parameters in the pre-epidemic TBE season. |
| first_indexed | 2024-03-08T12:17:19Z |
| format | Article |
| id | doaj.art-b8791441a3954d7b962715c8c7abdbab |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:18:30Z |
| publishDate | 2018-07-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-b8791441a3954d7b962715c8c7abdbab2024-03-28T07:49:20ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962018-07-0134424610.29413/ABS.2018-3.4.7640CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTIONG. N. Leonova0Somov Research Institute of Epidemiology and MicrobiologyThe subdivision of the viral population into subtypes and clusters based on the molecular genetic characteristics of the tick-borne encephalitis virus (TBEV) strains predetermines not only the differences in the biological properties of these strains, but also their different responses to specific antibodies in persons vaccinated against TBE.The aim of the present study is to show the differences in biological properties on the model of two strains of Far Eastern TBEV subtype belonging to different clusters and to substantiate the need for a personalized approach to the vaccine prophylaxis of tick-borne encephalitis.Results. Two strains of TBEV were used in the studies. On the basis of full genome sequencing the Dal’negorsk strain (FJ402886, GenBank) is referred to the typical representative of Sofjin-like, and Primorye-437 (JQ825162, GenBank) – to Oshima-like TBEV strains of the Far Eastern subtype.The experiment shows the levels of specific antibodies capable of neutralizing virulence strains of tick- borne encephalitis virus. Low antibody titers (1:100 and 1:400) can neutralize only a low dose of a non-virulent strain of tick-borne encephalitis virus. Reliable protection against the disease of people infected with virulent strains of the TBEV can provide only a high level of specific antibodies.Conclusion. If the level of specific antibodies of IgG is 1:400 or lower, the vaccination course should be continued, at a titer of antibodies above 1:400, revaccination can be postponed subject to annual monitoring of specific immunity parameters in the pre-epidemic TBE season.https://www.actabiomedica.ru/jour/article/view/648tbev strainspathogenicityspecific igg |
| spellingShingle | G. N. Leonova CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION Acta Biomedica Scientifica tbev strains pathogenicity specific igg |
| title | CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION |
| title_full | CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION |
| title_fullStr | CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION |
| title_full_unstemmed | CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION |
| title_short | CHARACTERISTICS OF THE FAR EASTERN POPULATION OF TICK-BORNE ENCEPHALITIS VIRUS AND SOLVING ISSUES OF SPECIFIC PREVENTION |
| title_sort | characteristics of the far eastern population of tick borne encephalitis virus and solving issues of specific prevention |
| topic | tbev strains pathogenicity specific igg |
| url | https://www.actabiomedica.ru/jour/article/view/648 |
| work_keys_str_mv | AT gnleonova characteristicsofthefareasternpopulationoftickborneencephalitisvirusandsolvingissuesofspecificprevention |