Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers
Gene therapy has been used as a potential approach to address the diagnosis and treatment of genetic diseases and inherited disorders. In this line, non-viral systems have been exploited as promising alternatives for delivering therapeutic transgenes and proteins. In this review, we explored how bio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/3/428 |
| _version_ | 1797540446524669952 |
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| author | Julian D. Torres-Vanegas Juan C. Cruz Luis H. Reyes |
| author_facet | Julian D. Torres-Vanegas Juan C. Cruz Luis H. Reyes |
| author_sort | Julian D. Torres-Vanegas |
| collection | DOAJ |
| description | Gene therapy has been used as a potential approach to address the diagnosis and treatment of genetic diseases and inherited disorders. In this line, non-viral systems have been exploited as promising alternatives for delivering therapeutic transgenes and proteins. In this review, we explored how biological barriers are effectively overcome by non-viral systems, usually nanoparticles, to reach an efficient delivery of cargoes. Furthermore, this review contributes to the understanding of several mechanisms of cellular internalization taken by nanoparticles. Because a critical factor for nanoparticles to do this relies on the ability to escape endosomes, researchers have dedicated much effort to address this issue using different nanocarriers. Here, we present an overview of the diversity of nanovehicles explored to reach an efficient and effective delivery of both nucleic acids and proteins. Finally, we introduced recent advances in the development of successful strategies to deliver cargoes. |
| first_indexed | 2024-03-10T13:01:15Z |
| format | Article |
| id | doaj.art-b8798e55b16c43b3ad150cbe6083f3f1 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T13:01:15Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-b8798e55b16c43b3ad150cbe6083f3f12023-11-21T11:30:11ZengMDPI AGPharmaceutics1999-49232021-03-0113342810.3390/pharmaceutics13030428Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and NanocarriersJulian D. Torres-Vanegas0Juan C. Cruz1Luis H. Reyes2Grupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, ColombiaDepartment of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, ColombiaGrupo de Diseño de Productos y Procesos (GDPP), Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, ColombiaGene therapy has been used as a potential approach to address the diagnosis and treatment of genetic diseases and inherited disorders. In this line, non-viral systems have been exploited as promising alternatives for delivering therapeutic transgenes and proteins. In this review, we explored how biological barriers are effectively overcome by non-viral systems, usually nanoparticles, to reach an efficient delivery of cargoes. Furthermore, this review contributes to the understanding of several mechanisms of cellular internalization taken by nanoparticles. Because a critical factor for nanoparticles to do this relies on the ability to escape endosomes, researchers have dedicated much effort to address this issue using different nanocarriers. Here, we present an overview of the diversity of nanovehicles explored to reach an efficient and effective delivery of both nucleic acids and proteins. Finally, we introduced recent advances in the development of successful strategies to deliver cargoes.https://www.mdpi.com/1999-4923/13/3/428gene therapyinternalizationnanovehiclesdelivery |
| spellingShingle | Julian D. Torres-Vanegas Juan C. Cruz Luis H. Reyes Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers Pharmaceutics gene therapy internalization nanovehicles delivery |
| title | Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers |
| title_full | Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers |
| title_fullStr | Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers |
| title_full_unstemmed | Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers |
| title_short | Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers |
| title_sort | delivery systems for nucleic acids and proteins barriers cell capture pathways and nanocarriers |
| topic | gene therapy internalization nanovehicles delivery |
| url | https://www.mdpi.com/1999-4923/13/3/428 |
| work_keys_str_mv | AT juliandtorresvanegas deliverysystemsfornucleicacidsandproteinsbarrierscellcapturepathwaysandnanocarriers AT juanccruz deliverysystemsfornucleicacidsandproteinsbarrierscellcapturepathwaysandnanocarriers AT luishreyes deliverysystemsfornucleicacidsandproteinsbarrierscellcapturepathwaysandnanocarriers |