Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis
Abstract Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiotherapy, highlight the need for new therap...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Chinese Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13020-024-00918-w |
| _version_ | 1827309958689980416 |
|---|---|
| author | Tian Chen Lu Ding Meiru Zhao Siyu Song Juan Hou Xueyan Li Min Li Kai Yin Xiangyan Li Zeyu Wang |
| author_facet | Tian Chen Lu Ding Meiru Zhao Siyu Song Juan Hou Xueyan Li Min Li Kai Yin Xiangyan Li Zeyu Wang |
| author_sort | Tian Chen |
| collection | DOAJ |
| description | Abstract Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiotherapy, highlight the need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability to target multiple pathways and mechanisms. Active compounds from Chinese herbs and other natural sources exhibit anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects, making them valuable in preventing and treating respiratory conditions. Ferroptosis, a unique form of programmed cell death (PCD) distinct from apoptosis, necrosis, and others, has emerged as a key area of interest. However, comprehensive reviews on how natural products influence ferroptosis in respiratory diseases are lacking. This review will explore the therapeutic potential and mechanisms of natural products from TCM in modulating ferroptosis for respiratory diseases like acute lung injury (ALI), asthma, pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), lung ischemia–reperfusion injury (LIRI), pulmonary hypertension (PH), and lung cancer, aiming to provide new insights for research and clinical application in TCM for respiratory health. |
| first_indexed | 2024-04-24T19:52:02Z |
| format | Article |
| id | doaj.art-b87a0ba8d69e4204aa1b7c64142cc81d |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-04-24T19:52:02Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-b87a0ba8d69e4204aa1b7c64142cc81d2024-03-24T12:33:54ZengBMCChinese Medicine1749-85462024-03-0119113310.1186/s13020-024-00918-wRecent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosisTian Chen0Lu Ding1Meiru Zhao2Siyu Song3Juan Hou4Xueyan Li5Min Li6Kai Yin7Xiangyan Li8Zeyu Wang9College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese MedicineNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese MedicineCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese MedicineNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese MedicineCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese MedicineCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese MedicineCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese MedicineCollege of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese MedicineNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese MedicineNortheast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efficacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese MedicineAbstract Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases, respiratory failure. The side effects of current treatments, such as hormone therapy, drugs, and radiotherapy, highlight the need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability to target multiple pathways and mechanisms. Active compounds from Chinese herbs and other natural sources exhibit anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects, making them valuable in preventing and treating respiratory conditions. Ferroptosis, a unique form of programmed cell death (PCD) distinct from apoptosis, necrosis, and others, has emerged as a key area of interest. However, comprehensive reviews on how natural products influence ferroptosis in respiratory diseases are lacking. This review will explore the therapeutic potential and mechanisms of natural products from TCM in modulating ferroptosis for respiratory diseases like acute lung injury (ALI), asthma, pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), lung ischemia–reperfusion injury (LIRI), pulmonary hypertension (PH), and lung cancer, aiming to provide new insights for research and clinical application in TCM for respiratory health.https://doi.org/10.1186/s13020-024-00918-wTCMNatural productsFerroptosisRespiratory diseasesMechanism |
| spellingShingle | Tian Chen Lu Ding Meiru Zhao Siyu Song Juan Hou Xueyan Li Min Li Kai Yin Xiangyan Li Zeyu Wang Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis Chinese Medicine TCM Natural products Ferroptosis Respiratory diseases Mechanism |
| title | Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis |
| title_full | Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis |
| title_fullStr | Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis |
| title_full_unstemmed | Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis |
| title_short | Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis |
| title_sort | recent advances in the potential effects of natural products from traditional chinese medicine against respiratory diseases targeting ferroptosis |
| topic | TCM Natural products Ferroptosis Respiratory diseases Mechanism |
| url | https://doi.org/10.1186/s13020-024-00918-w |
| work_keys_str_mv | AT tianchen recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT luding recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT meiruzhao recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT siyusong recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT juanhou recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT xueyanli recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT minli recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT kaiyin recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT xiangyanli recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis AT zeyuwang recentadvancesinthepotentialeffectsofnaturalproductsfromtraditionalchinesemedicineagainstrespiratorydiseasestargetingferroptosis |