An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats

Fentanyl (FEN) is a potent synthetic opioid associated with increasing incidence of opioid use disorder (OUD) and fatal opioid overdose. Vaccine immunotherapy for FEN-associated disorders may be a viable therapeutic strategy. Here, we expand and confirm our previous study in mice showing immunologic...

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Bibliographic Details
Main Authors: Colin N. Haile, Miah D. Baker, Sergio A. Sanchez, Carlos A. Lopez Arteaga, Anantha L. Duddupudi, Gregory D. Cuny, Elizabeth B. Norton, Thomas R. Kosten, Therese A. Kosten
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pharmaceutics
Subjects:
opioids
analgesia
overdose
vaccines
conjugate
adjuvant
Online Access:https://www.mdpi.com/1999-4923/14/11/2290

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