Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes
The regulation of protein synthesis is of extreme importance for cell survival in challenging environmental conditions. Modulating gene expression at the level of translation allows a swift and low-energy-cost response to external stimuli. In the last decade, an emerging class of regulatory ncRNAs,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/8/2/22 |
| _version_ | 1827627411895746560 |
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| author | Valentina Pecoraro Alessia Rosina Norbert Polacek |
| author_facet | Valentina Pecoraro Alessia Rosina Norbert Polacek |
| author_sort | Valentina Pecoraro |
| collection | DOAJ |
| description | The regulation of protein synthesis is of extreme importance for cell survival in challenging environmental conditions. Modulating gene expression at the level of translation allows a swift and low-energy-cost response to external stimuli. In the last decade, an emerging class of regulatory ncRNAs, namely ribosome-associated non-coding RNAs (rancRNAs), has been discovered. These rancRNAs have proven to be efficient players in the regulation of translation as a first wave of stress adaptation by directly targeting the ribosome, the central enzyme of protein production. This underlying principle appears to be highly conserved, since rancRNAs are present in all three domains of life. Here, we review the major findings and mechanistic peculiarities of rancRNAs, a class of transcripts that is providing new and broader perspectives on the complexity of the ribosome and translation regulation. |
| first_indexed | 2024-03-09T13:12:53Z |
| format | Article |
| id | doaj.art-b87b88d32c8c4070a055c9771ae01506 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-09T13:12:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-b87b88d32c8c4070a055c9771ae015062023-11-30T21:40:25ZengMDPI AGNon-Coding RNA2311-553X2022-03-01822210.3390/ncrna8020022Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape ProteomesValentina Pecoraro0Alessia Rosina1Norbert Polacek2Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, SwitzerlandDepartment of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, 3012 Bern, SwitzerlandThe regulation of protein synthesis is of extreme importance for cell survival in challenging environmental conditions. Modulating gene expression at the level of translation allows a swift and low-energy-cost response to external stimuli. In the last decade, an emerging class of regulatory ncRNAs, namely ribosome-associated non-coding RNAs (rancRNAs), has been discovered. These rancRNAs have proven to be efficient players in the regulation of translation as a first wave of stress adaptation by directly targeting the ribosome, the central enzyme of protein production. This underlying principle appears to be highly conserved, since rancRNAs are present in all three domains of life. Here, we review the major findings and mechanistic peculiarities of rancRNAs, a class of transcripts that is providing new and broader perspectives on the complexity of the ribosome and translation regulation.https://www.mdpi.com/2311-553X/8/2/22translation controlstress responseribosome functionsnon-protein coding RNA |
| spellingShingle | Valentina Pecoraro Alessia Rosina Norbert Polacek Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes Non-Coding RNA translation control stress response ribosome functions non-protein coding RNA |
| title | Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes |
| title_full | Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes |
| title_fullStr | Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes |
| title_full_unstemmed | Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes |
| title_short | Ribosome-Associated ncRNAs (rancRNAs) Adjust Translation and Shape Proteomes |
| title_sort | ribosome associated ncrnas rancrnas adjust translation and shape proteomes |
| topic | translation control stress response ribosome functions non-protein coding RNA |
| url | https://www.mdpi.com/2311-553X/8/2/22 |
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