Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study
Mustafa AA Osman,1 Mohamed Alkhouly,1 Ghada F Elmohaseb,2 Eman Mostafa Nassef,2 Ibrahim Ghonim Ramadan Mohamed,2 Ismail Mohamed El mancy,2 Seham Sabry,2 Marwa M Abdulrehim,2 Ahmed Eliwa,2 Yasmine H Eisa,3 Ahmed Abdel-Ghany,4 Yasser Abdelghani5 1Gynecology and Obstetrics Department, Al-Azhar Universi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/relation-between-non-alcoholic-fatty-pancreas-and-clinical-and-biochem-peer-reviewed-fulltext-article-IJGM |
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| author | Osman MAA Alkhouly M Elmohaseb GF Nassef EM Mohamed IGR El mancy IM Sabry S Abdulrehim MM Eliwa A Eisa YH Abdel-Ghany A Abdelghani Y |
| author_facet | Osman MAA Alkhouly M Elmohaseb GF Nassef EM Mohamed IGR El mancy IM Sabry S Abdulrehim MM Eliwa A Eisa YH Abdel-Ghany A Abdelghani Y |
| author_sort | Osman MAA |
| collection | DOAJ |
| description | Mustafa AA Osman,1 Mohamed Alkhouly,1 Ghada F Elmohaseb,2 Eman Mostafa Nassef,2 Ibrahim Ghonim Ramadan Mohamed,2 Ismail Mohamed El mancy,2 Seham Sabry,2 Marwa M Abdulrehim,2 Ahmed Eliwa,2 Yasmine H Eisa,3 Ahmed Abdel-Ghany,4 Yasser Abdelghani5 1Gynecology and Obstetrics Department, Al-Azhar University, Cairo, Egypt; 2Internal Medicine Department, Al-Azhar University, Cairo, Egypt; 3Community Medicine Department, October 6 University, Giza, Egypt; 4Gynecology and Obstetrics Department, Minia University, Minia, Egypt; 5Tropical Medicine Department, Minia University, Minia, EgyptCorrespondence: Eman Mostafa Nassef, Internal Medicine Department, Al-Azhar University, Cairo, Egypt, Tel +20 1098002232, Email nassef.eman@yahoo.comBackground: Polycystic ovary syndrome (PCOS) is the most common endocrinological disease affecting women in the reproductive age. Non-alcoholic fatty pancreas disease (NAFPD) can promote many aspects of pancreatic dysfunction. The present study aimed to determine the prevalence of NAFPD and to identify its association with clinical and biochemical parameters in PCOS patients.Methods: The present study included 150 patients with PCOS and 150 age-matched healthy controls. All patients were submitted to careful history taking and thorough clinical examination. Performed laboratory investigations included fasting and postprandial blood glucose, lipid profile, liver function tests, serum prolactin and total testosterone. Fatty pancreas was diagnosed using abdominal ultrasound.Results: Among PCOS women, NAFPD was diagnosed in 57 women (38.0%) in contrast to 18 women (12.0%) in the control group (p < 0.001). Patients with NAFPD were significantly older [median (IQR): 38.0 (35.0– 43.0) versus 29.0 (25.5– 33.0) years, p = 0.001] with higher BMI [median (IQR): 31.5 (29.1– 34.7) versus 30.4 (28.6– 32.4) kg/m2, 0.042]. Moreover, they had significantly higher frequency of metabolic syndrome (84.2% versus 54.8%, p = 0.001), insulin resistance (68.4% versus 26.9%, p < 0.001) and severe NAFLD (22.8% versus 2.2%, p < 0.001). NAFPD patients had significantly lower sex hormone binding globulin (SHBG) [median (IQR): 36.0 (30.8– 40.7) versus 38.1 (35.15– 42.7), p = 0.002] and significantly higher free androgen index (FAI) [median (IQR): 4.08 (3.3– 4.92) versus 3.47 (3.12– 4.05), p < 0.001].Conclusion: NAFPD is prevalent PCOS. It is related to metabolic syndrome, insulin resistance, dyslipidemia and hyperandrogenism.Keywords: polycystic ovary, non-alcoholic fatty pancreas, free androgen index |
| first_indexed | 2024-04-12T06:29:39Z |
| format | Article |
| id | doaj.art-b87b8f2401074eb4b0e78a62fd0f35ff |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-12T06:29:39Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-b87b8f2401074eb4b0e78a62fd0f35ff2022-12-22T03:44:04ZengDove Medical PressInternational Journal of General Medicine1178-70742022-11-01Volume 158225823379767Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric StudyOsman MAAAlkhouly MElmohaseb GFNassef EMMohamed IGREl mancy IMSabry SAbdulrehim MMEliwa AEisa YHAbdel-Ghany AAbdelghani YMustafa AA Osman,1 Mohamed Alkhouly,1 Ghada F Elmohaseb,2 Eman Mostafa Nassef,2 Ibrahim Ghonim Ramadan Mohamed,2 Ismail Mohamed El mancy,2 Seham Sabry,2 Marwa M Abdulrehim,2 Ahmed Eliwa,2 Yasmine H Eisa,3 Ahmed Abdel-Ghany,4 Yasser Abdelghani5 1Gynecology and Obstetrics Department, Al-Azhar University, Cairo, Egypt; 2Internal Medicine Department, Al-Azhar University, Cairo, Egypt; 3Community Medicine Department, October 6 University, Giza, Egypt; 4Gynecology and Obstetrics Department, Minia University, Minia, Egypt; 5Tropical Medicine Department, Minia University, Minia, EgyptCorrespondence: Eman Mostafa Nassef, Internal Medicine Department, Al-Azhar University, Cairo, Egypt, Tel +20 1098002232, Email nassef.eman@yahoo.comBackground: Polycystic ovary syndrome (PCOS) is the most common endocrinological disease affecting women in the reproductive age. Non-alcoholic fatty pancreas disease (NAFPD) can promote many aspects of pancreatic dysfunction. The present study aimed to determine the prevalence of NAFPD and to identify its association with clinical and biochemical parameters in PCOS patients.Methods: The present study included 150 patients with PCOS and 150 age-matched healthy controls. All patients were submitted to careful history taking and thorough clinical examination. Performed laboratory investigations included fasting and postprandial blood glucose, lipid profile, liver function tests, serum prolactin and total testosterone. Fatty pancreas was diagnosed using abdominal ultrasound.Results: Among PCOS women, NAFPD was diagnosed in 57 women (38.0%) in contrast to 18 women (12.0%) in the control group (p < 0.001). Patients with NAFPD were significantly older [median (IQR): 38.0 (35.0– 43.0) versus 29.0 (25.5– 33.0) years, p = 0.001] with higher BMI [median (IQR): 31.5 (29.1– 34.7) versus 30.4 (28.6– 32.4) kg/m2, 0.042]. Moreover, they had significantly higher frequency of metabolic syndrome (84.2% versus 54.8%, p = 0.001), insulin resistance (68.4% versus 26.9%, p < 0.001) and severe NAFLD (22.8% versus 2.2%, p < 0.001). NAFPD patients had significantly lower sex hormone binding globulin (SHBG) [median (IQR): 36.0 (30.8– 40.7) versus 38.1 (35.15– 42.7), p = 0.002] and significantly higher free androgen index (FAI) [median (IQR): 4.08 (3.3– 4.92) versus 3.47 (3.12– 4.05), p < 0.001].Conclusion: NAFPD is prevalent PCOS. It is related to metabolic syndrome, insulin resistance, dyslipidemia and hyperandrogenism.Keywords: polycystic ovary, non-alcoholic fatty pancreas, free androgen indexhttps://www.dovepress.com/relation-between-non-alcoholic-fatty-pancreas-and-clinical-and-biochem-peer-reviewed-fulltext-article-IJGMpolycystic ovarynon-alcoholic fatty pancreasfree androgen index. |
| spellingShingle | Osman MAA Alkhouly M Elmohaseb GF Nassef EM Mohamed IGR El mancy IM Sabry S Abdulrehim MM Eliwa A Eisa YH Abdel-Ghany A Abdelghani Y Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study International Journal of General Medicine polycystic ovary non-alcoholic fatty pancreas free androgen index. |
| title | Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study |
| title_full | Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study |
| title_fullStr | Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study |
| title_full_unstemmed | Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study |
| title_short | Relation Between Non-Alcoholic Fatty Pancreas and Clinical and Biochemical Parameters in Women with Polycystic Ovary Syndrome: A Multi-Centric Study |
| title_sort | relation between non alcoholic fatty pancreas and clinical and biochemical parameters in women with polycystic ovary syndrome a multi centric study |
| topic | polycystic ovary non-alcoholic fatty pancreas free androgen index. |
| url | https://www.dovepress.com/relation-between-non-alcoholic-fatty-pancreas-and-clinical-and-biochem-peer-reviewed-fulltext-article-IJGM |
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