Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis
Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis sugg...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25730-0 |
| _version_ | 1818845049784369152 |
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| author | David M. Zhang Rachita Navara Tiankai Yin Jeffrey Szymanski Uri Goldsztejn Camryn Kenkel Adam Lang Cedric Mpoy Catherine E. Lipovsky Yun Qiao Stephanie Hicks Gang Li Kaitlin M. S. Moore Carmen Bergom Buck E. Rogers Clifford G. Robinson Phillip S. Cuculich Julie K. Schwarz Stacey L. Rentschler |
| author_facet | David M. Zhang Rachita Navara Tiankai Yin Jeffrey Szymanski Uri Goldsztejn Camryn Kenkel Adam Lang Cedric Mpoy Catherine E. Lipovsky Yun Qiao Stephanie Hicks Gang Li Kaitlin M. S. Moore Carmen Bergom Buck E. Rogers Clifford G. Robinson Phillip S. Cuculich Julie K. Schwarz Stacey L. Rentschler |
| author_sort | David M. Zhang |
| collection | DOAJ |
| description | Noninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility. |
| first_indexed | 2024-12-19T05:23:29Z |
| format | Article |
| id | doaj.art-b87d769fbd7248d484a32dad47327e5a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T05:23:29Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b87d769fbd7248d484a32dad47327e5a2022-12-21T20:34:26ZengNature PortfolioNature Communications2041-17232021-09-0112111410.1038/s41467-021-25730-0Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosisDavid M. Zhang0Rachita Navara1Tiankai Yin2Jeffrey Szymanski3Uri Goldsztejn4Camryn Kenkel5Adam Lang6Cedric Mpoy7Catherine E. Lipovsky8Yun Qiao9Stephanie Hicks10Gang Li11Kaitlin M. S. Moore12Carmen Bergom13Buck E. Rogers14Clifford G. Robinson15Phillip S. Cuculich16Julie K. Schwarz17Stacey L. Rentschler18Center for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineDepartment of Radiation Oncology, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineDepartment of Pathology, Washington University in St. Louis, School of MedicineDepartment of Radiation Oncology, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineDepartment of Radiation Oncology, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineCenter for Noninvasive Cardiac Radioablation, Washington University in St. Louis, School of MedicineNoninvasive cardiac radiotherapy may effectively manage ventricular tachycardia in refractory patients, but its radiobiologic mechanisms of action are unclear. Here, the authors show that photon radiation durably and favourably reprograms cardiac conduction in the absence of transmural fibrosis suggesting this could be the mechanism through which cardiac radiotherapy to modulates arrhythmia susceptibility.https://doi.org/10.1038/s41467-021-25730-0 |
| spellingShingle | David M. Zhang Rachita Navara Tiankai Yin Jeffrey Szymanski Uri Goldsztejn Camryn Kenkel Adam Lang Cedric Mpoy Catherine E. Lipovsky Yun Qiao Stephanie Hicks Gang Li Kaitlin M. S. Moore Carmen Bergom Buck E. Rogers Clifford G. Robinson Phillip S. Cuculich Julie K. Schwarz Stacey L. Rentschler Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis Nature Communications |
| title | Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis |
| title_full | Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis |
| title_fullStr | Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis |
| title_full_unstemmed | Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis |
| title_short | Cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis |
| title_sort | cardiac radiotherapy induces electrical conduction reprogramming in the absence of transmural fibrosis |
| url | https://doi.org/10.1038/s41467-021-25730-0 |
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