Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection
Peng Li,1,2 Lei Gao,1– 3 Chenlu Gao,1,2 Robert A Parker,4– 6 Ingrid T Katz,5,7,8 Monty A Montano,5,9 Kun Hu1,2 1Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2Divis...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-02-01
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| Series: | Nature and Science of Sleep |
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| Online Access: | https://www.dovepress.com/daytime-sleep-behaviors-and-cognitive-performance-in-middle--to-older--peer-reviewed-fulltext-article-NSS |
| _version_ | 1819274641471963136 |
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| author | Li P Gao L Gao C Parker RA Katz IT Montano MA Hu K |
| author_facet | Li P Gao L Gao C Parker RA Katz IT Montano MA Hu K |
| author_sort | Li P |
| collection | DOAJ |
| description | Peng Li,1,2 Lei Gao,1– 3 Chenlu Gao,1,2 Robert A Parker,4– 6 Ingrid T Katz,5,7,8 Monty A Montano,5,9 Kun Hu1,2 1Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; 3Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 4Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA; 5Harvard Medical School, Boston, MA, USA; 6Center for AIDS Research, Harvard University, Boston, MA, USA; 7Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 8Harvard Global Health Institute, Cambridge, MA, USA; 9Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USACorrespondence: Peng Li, Email pli9@bwh.harvard.eduPurpose: We investigated whether daytime sleep behaviors (DSBs) such as frequent daytime sleepiness or napping are associated with worse cognitive performance, and whether HIV infection moderates this relationship.Methods: Among 502,507 participants in the UK Biobank study, we identified 562 people living with HIV infection (PLWH; Mage= 50.51± 7.81; 25.09% female; 78.83% white) and extracted 562 uninfected controls who matched on age, sex, ethnic background, social-economic status, and comorbidities. DSB burden was assessed based on answers to two questions on DSBs. Participants who answered “sometimes” or “often/usually” to one of them were considered to have poor DSB burden, or otherwise were considered not having any. A composite cognition score was computed by averaging the available standardized individual test results from four neurocognitive tests: ie, a reaction time test for information processing speed, a pairs matching test for visual episodic memory, a fluid intelligence test for reasoning, and a prospective memory test. Mixed-effects models with adjustment for the variables used in extracting matched uninfected controls were performed to test the hypotheses.Results: Having poor DSB burden was associated with a 0.15 – standard deviation (SD) decrease in cognitive performance (p = 0.006). People living with HIV infection (PLWH) also performed worse on the cognitive tasks than uninfected controls, with an effect size similar to that of having poor DSB burden (p = 0.003). HIV infection significantly modified the negative association between DSB burden and cognition (p for interaction: 0.008). Specifically, the association between DSB burden and cognition was not statistically significant in uninfected controls, whereas PLWH who reported having poor DSB burden had a 0.28 – SD decrease in cognitive performance compared to PLWH who did not.Conclusion: HIV infection significantly increased the adverse association between DSBs and cognitive performance. Further studies are needed to investigate the potential mechanisms that underlie this interaction effect and whether poor DSBs and worse cognitive performance are causally linked.Keywords: aging, cognition, daytime napping, daytime sleepiness, risk factors, sleep |
| first_indexed | 2024-12-23T23:11:40Z |
| format | Article |
| id | doaj.art-b87faf555363410ca1a80e43d2b74ed8 |
| institution | Directory Open Access Journal |
| issn | 1179-1608 |
| language | English |
| last_indexed | 2024-12-23T23:11:40Z |
| publishDate | 2022-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Nature and Science of Sleep |
| spelling | doaj.art-b87faf555363410ca1a80e43d2b74ed82022-12-21T17:26:39ZengDove Medical PressNature and Science of Sleep1179-16082022-02-01Volume 1418119172825Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV InfectionLi PGao LGao CParker RAKatz ITMontano MAHu KPeng Li,1,2 Lei Gao,1– 3 Chenlu Gao,1,2 Robert A Parker,4– 6 Ingrid T Katz,5,7,8 Monty A Montano,5,9 Kun Hu1,2 1Medical Biodynamics Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 2Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA; 3Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; 4Biostatistics Center, Massachusetts General Hospital, Boston, MA, USA; 5Harvard Medical School, Boston, MA, USA; 6Center for AIDS Research, Harvard University, Boston, MA, USA; 7Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; 8Harvard Global Health Institute, Cambridge, MA, USA; 9Boston Claude D. Pepper Older Americans Independence Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USACorrespondence: Peng Li, Email pli9@bwh.harvard.eduPurpose: We investigated whether daytime sleep behaviors (DSBs) such as frequent daytime sleepiness or napping are associated with worse cognitive performance, and whether HIV infection moderates this relationship.Methods: Among 502,507 participants in the UK Biobank study, we identified 562 people living with HIV infection (PLWH; Mage= 50.51± 7.81; 25.09% female; 78.83% white) and extracted 562 uninfected controls who matched on age, sex, ethnic background, social-economic status, and comorbidities. DSB burden was assessed based on answers to two questions on DSBs. Participants who answered “sometimes” or “often/usually” to one of them were considered to have poor DSB burden, or otherwise were considered not having any. A composite cognition score was computed by averaging the available standardized individual test results from four neurocognitive tests: ie, a reaction time test for information processing speed, a pairs matching test for visual episodic memory, a fluid intelligence test for reasoning, and a prospective memory test. Mixed-effects models with adjustment for the variables used in extracting matched uninfected controls were performed to test the hypotheses.Results: Having poor DSB burden was associated with a 0.15 – standard deviation (SD) decrease in cognitive performance (p = 0.006). People living with HIV infection (PLWH) also performed worse on the cognitive tasks than uninfected controls, with an effect size similar to that of having poor DSB burden (p = 0.003). HIV infection significantly modified the negative association between DSB burden and cognition (p for interaction: 0.008). Specifically, the association between DSB burden and cognition was not statistically significant in uninfected controls, whereas PLWH who reported having poor DSB burden had a 0.28 – SD decrease in cognitive performance compared to PLWH who did not.Conclusion: HIV infection significantly increased the adverse association between DSBs and cognitive performance. Further studies are needed to investigate the potential mechanisms that underlie this interaction effect and whether poor DSBs and worse cognitive performance are causally linked.Keywords: aging, cognition, daytime napping, daytime sleepiness, risk factors, sleephttps://www.dovepress.com/daytime-sleep-behaviors-and-cognitive-performance-in-middle--to-older--peer-reviewed-fulltext-article-NSSagingcognitiondaytime nappingdaytime sleepinessrisk factorssleep |
| spellingShingle | Li P Gao L Gao C Parker RA Katz IT Montano MA Hu K Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection Nature and Science of Sleep aging cognition daytime napping daytime sleepiness risk factors sleep |
| title | Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection |
| title_full | Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection |
| title_fullStr | Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection |
| title_full_unstemmed | Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection |
| title_short | Daytime Sleep Behaviors and Cognitive Performance in Middle- to Older-Aged Adults Living with and without HIV Infection |
| title_sort | daytime sleep behaviors and cognitive performance in middle to older aged adults living with and without hiv infection |
| topic | aging cognition daytime napping daytime sleepiness risk factors sleep |
| url | https://www.dovepress.com/daytime-sleep-behaviors-and-cognitive-performance-in-middle--to-older--peer-reviewed-fulltext-article-NSS |
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