The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult
Objective To explore the role of adiponectin-resistin (AR) index as a better indicator of obesity-related hypertension. Method(s) This study continued a case control study that had finished recruiting 153 subjects divided as four characteristic groups. Fasting serum resistin levels (FSR) and Fasting...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2021.1984500 |
| _version_ | 1827814043598979072 |
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| author | Ou Wu Jian Hang Leng Xing Yu Zhang Wei Liu Hu Zhang Fen Fang Yang Jia Jia Li Guo Zhong Zhang Xi Lu |
| author_facet | Ou Wu Jian Hang Leng Xing Yu Zhang Wei Liu Hu Zhang Fen Fang Yang Jia Jia Li Guo Zhong Zhang Xi Lu |
| author_sort | Ou Wu |
| collection | DOAJ |
| description | Objective To explore the role of adiponectin-resistin (AR) index as a better indicator of obesity-related hypertension. Method(s) This study continued a case control study that had finished recruiting 153 subjects divided as four characteristic groups. Fasting serum resistin levels (FSR) and Fasting serum adiponectin levels (FSA) were tested by ELISA. And, other related anthropometric clinical and metabolic data were collected. Analyzation on correlations between research index and differences between groups were done by SPSS. AR index’s performance was also validated by the receiver operating characteristic (ROC) curves, the net reclassification improvement (NRI), and the integrated discrimination improvement (IDI). Result(s) The AR index was defined as 1+ log10(R0)-log10(A0). AUC of the AR index was 0.660 and NRI and IDI indicated AR index outperformed FSA alone. AR index statistically significantly negatively correlated with SB and DB and positively with ALB and SCR. AR index was statistically significantly different between the NH group and OH group and more specific than FSR alone as a biomarker of obesity-related hypertension. Conclusion(s) The AR index was more strongly associated with increased risk of obesity-related hypertension than the solely index of FSR or FSA and was useful for early diagnosis of obesity-related hypertension. |
| first_indexed | 2024-03-11T23:40:13Z |
| format | Article |
| id | doaj.art-b87fdd856cfe4288998d027ff95e1cf9 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:40:13Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-b87fdd856cfe4288998d027ff95e1cf92023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-01-01441404510.1080/10641963.2021.19845001984500The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adultOu Wu0Jian Hang Leng1Xing Yu Zhang2Wei Liu3Hu Zhang4Fen Fang Yang5Jia Jia Li6Guo Zhong Zhang7Xi Lu8Zhejiang Shuren UniversityThe First People’s Hospital of HangzhouUniversity of Pittsburgh Medical CenterLTDSir Run Run Shaw Hospital Affiliated with Medical College of Zhejiang UniversityThe First People’s Hospital of HangzhouThe First Affiliated Hospital of Anhui Medical UniversityHangzhou Center for Disease Control and PreventionHangzhou Vocational and Technical CollegeObjective To explore the role of adiponectin-resistin (AR) index as a better indicator of obesity-related hypertension. Method(s) This study continued a case control study that had finished recruiting 153 subjects divided as four characteristic groups. Fasting serum resistin levels (FSR) and Fasting serum adiponectin levels (FSA) were tested by ELISA. And, other related anthropometric clinical and metabolic data were collected. Analyzation on correlations between research index and differences between groups were done by SPSS. AR index’s performance was also validated by the receiver operating characteristic (ROC) curves, the net reclassification improvement (NRI), and the integrated discrimination improvement (IDI). Result(s) The AR index was defined as 1+ log10(R0)-log10(A0). AUC of the AR index was 0.660 and NRI and IDI indicated AR index outperformed FSA alone. AR index statistically significantly negatively correlated with SB and DB and positively with ALB and SCR. AR index was statistically significantly different between the NH group and OH group and more specific than FSR alone as a biomarker of obesity-related hypertension. Conclusion(s) The AR index was more strongly associated with increased risk of obesity-related hypertension than the solely index of FSR or FSA and was useful for early diagnosis of obesity-related hypertension.http://dx.doi.org/10.1080/10641963.2021.1984500adiponectin-resistin index (ar index)obesityhypertensionblood pressurevalidity |
| spellingShingle | Ou Wu Jian Hang Leng Xing Yu Zhang Wei Liu Hu Zhang Fen Fang Yang Jia Jia Li Guo Zhong Zhang Xi Lu The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult Clinical and Experimental Hypertension adiponectin-resistin index (ar index) obesity hypertension blood pressure validity |
| title | The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult |
| title_full | The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult |
| title_fullStr | The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult |
| title_full_unstemmed | The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult |
| title_short | The value of adiponectin-resistin (AR) index in newly diagnosed obesity hypertension: a case control study among Chinese adult |
| title_sort | value of adiponectin resistin ar index in newly diagnosed obesity hypertension a case control study among chinese adult |
| topic | adiponectin-resistin index (ar index) obesity hypertension blood pressure validity |
| url | http://dx.doi.org/10.1080/10641963.2021.1984500 |
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