The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus
Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be associated with complications and HbA1c. This cross-sectional observational study of 81 children and adolescents of both sexes di...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/11/4/125 |
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| author | Thais Menegucci Eduardo Federighi Baisi Chagas Barbara de Oliveira Zanuso Karina Quesada Jesselina Francisco dos Santos Haber Tereza Laís Menegucci Zutin Luis Felipe Pimenta Adriano Cressoni Araújo Elen Landgraf Guiguer Claudia Rucco P. Detregiachi Marcia Gabaldi Rocha Patrícia Cincotto dos Santos Bueno Lucas Fornari Laurindo Sandra M. Barbalho |
| author_facet | Thais Menegucci Eduardo Federighi Baisi Chagas Barbara de Oliveira Zanuso Karina Quesada Jesselina Francisco dos Santos Haber Tereza Laís Menegucci Zutin Luis Felipe Pimenta Adriano Cressoni Araújo Elen Landgraf Guiguer Claudia Rucco P. Detregiachi Marcia Gabaldi Rocha Patrícia Cincotto dos Santos Bueno Lucas Fornari Laurindo Sandra M. Barbalho |
| author_sort | Thais Menegucci |
| collection | DOAJ |
| description | Glycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be associated with complications and HbA1c. This cross-sectional observational study of 81 children and adolescents of both sexes diagnosed with DM1 investigated the relationship between body fat distribution and lean mass with HbA1C and apolipoprotein values, analyzing biochemical and body composition measurements. A Shapiro–Wilk test with Lilliefors correction, a non-parametric Mann–Whitney test, and others were used with a significance level of 5%. The sample had a diagnosis time of 4.32 years and high blood glucose levels (mean 178.19 mg/dL) and HbA1c (mean 8.57%). Subjects also had a moderate level of adiposity, as indicated by arm and thigh fat areas. The study also found significant differences in the distribution of patients concerning levels of apolipoproteins A and B, with a smaller proportion of patients having undesirable levels. Finally, the study found a significant difference in the distribution of patients with estimated cardiovascular risk based on the ApoB/ApoA-I ratio. Conclusively, visceral fat in children and adolescents with DM1 may increase the risk of DM1 long-term complications owing to its association with elevated HbA1C and apolipoprotein values. |
| first_indexed | 2024-03-08T20:51:01Z |
| format | Article |
| id | doaj.art-b87fec422f0c452fb73c1f4649aa7913 |
| institution | Directory Open Access Journal |
| issn | 2079-9721 |
| language | English |
| last_indexed | 2024-03-08T20:51:01Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj.art-b87fec422f0c452fb73c1f4649aa79132023-12-22T14:03:28ZengMDPI AGDiseases2079-97212023-09-0111412510.3390/diseases11040125The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes MellitusThais Menegucci0Eduardo Federighi Baisi Chagas1Barbara de Oliveira Zanuso2Karina Quesada3Jesselina Francisco dos Santos Haber4Tereza Laís Menegucci Zutin5Luis Felipe Pimenta6Adriano Cressoni Araújo7Elen Landgraf Guiguer8Claudia Rucco P. Detregiachi9Marcia Gabaldi Rocha10Patrícia Cincotto dos Santos Bueno11Lucas Fornari Laurindo12Sandra M. Barbalho13Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilInterdisciplinary Center on Diabetes (CENID), Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilDepartment of Animal Sciences, School of Veterinary Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilDepartment of Biochemistry and Pharmacology, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilPostgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília 17525-902, São Paulo, BrazilGlycated hemoglobin (HbA1c) is used to assess glycemic control in Type 1 diabetes (DM1) patients. Apolipoproteins play an essential role in DM1 pathophysiology and may be associated with complications and HbA1c. This cross-sectional observational study of 81 children and adolescents of both sexes diagnosed with DM1 investigated the relationship between body fat distribution and lean mass with HbA1C and apolipoprotein values, analyzing biochemical and body composition measurements. A Shapiro–Wilk test with Lilliefors correction, a non-parametric Mann–Whitney test, and others were used with a significance level of 5%. The sample had a diagnosis time of 4.32 years and high blood glucose levels (mean 178.19 mg/dL) and HbA1c (mean 8.57%). Subjects also had a moderate level of adiposity, as indicated by arm and thigh fat areas. The study also found significant differences in the distribution of patients concerning levels of apolipoproteins A and B, with a smaller proportion of patients having undesirable levels. Finally, the study found a significant difference in the distribution of patients with estimated cardiovascular risk based on the ApoB/ApoA-I ratio. Conclusively, visceral fat in children and adolescents with DM1 may increase the risk of DM1 long-term complications owing to its association with elevated HbA1C and apolipoprotein values.https://www.mdpi.com/2079-9721/11/4/125type 1 diabetes mellitusbody fatlean massglycated hemoglobinapolipoprotein |
| spellingShingle | Thais Menegucci Eduardo Federighi Baisi Chagas Barbara de Oliveira Zanuso Karina Quesada Jesselina Francisco dos Santos Haber Tereza Laís Menegucci Zutin Luis Felipe Pimenta Adriano Cressoni Araújo Elen Landgraf Guiguer Claudia Rucco P. Detregiachi Marcia Gabaldi Rocha Patrícia Cincotto dos Santos Bueno Lucas Fornari Laurindo Sandra M. Barbalho The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus Diseases type 1 diabetes mellitus body fat lean mass glycated hemoglobin apolipoprotein |
| title | The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus |
| title_full | The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus |
| title_fullStr | The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus |
| title_full_unstemmed | The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus |
| title_short | The Influence of Body Fat and Lean Mass on HbA1c and Lipid Profile in Children and Adolescents with Type 1 Diabetes Mellitus |
| title_sort | influence of body fat and lean mass on hba1c and lipid profile in children and adolescents with type 1 diabetes mellitus |
| topic | type 1 diabetes mellitus body fat lean mass glycated hemoglobin apolipoprotein |
| url | https://www.mdpi.com/2079-9721/11/4/125 |
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