The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane
Rheumatoid arthritis is a chronic inflammatory disease with a multifactorial etiology and varied course, which in the majority of patients leads to partial disability or to permanent handicap. Its characteristic trait is a persistent inflammation of the synovial membrane and the formation of an i...
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| Format: | Article |
| Language: | English |
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Sciendo
2012-06-01
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| Series: | Journal of Ultrasonography |
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| Online Access: | http://jultrason.pl/index.php/issues/volume-12-no-49/the-pathogenesis-of-rheumatoid-arthritis-in-radiological-studies-part-i-formation-of-inflammatory-infiltrates-within-the-synovial-membrane?aid=14 |
| _version_ | 1811219915380621312 |
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| author | Iwona Sudoł‑Szopińska Ewa Kontny Włodzimierz Maśliński Monika Prochorec‑Sobieszek Brygida Kwiatkowska Katarzyna Zaniewicz‑Kaniewska Agnieszka Warczyńska |
| author_facet | Iwona Sudoł‑Szopińska Ewa Kontny Włodzimierz Maśliński Monika Prochorec‑Sobieszek Brygida Kwiatkowska Katarzyna Zaniewicz‑Kaniewska Agnieszka Warczyńska |
| author_sort | Iwona Sudoł‑Szopińska |
| collection | DOAJ |
| description | Rheumatoid arthritis is a chronic inflammatory disease with a multifactorial etiology and
varied course, which in the majority of patients leads to partial disability or to permanent
handicap. Its characteristic trait is a persistent inflammation of the synovial membrane and
the formation of an invasive synovial tissue, called the pannus, which in time leads to destruction
of the cartilage, subchondral bone tissue, and the soft tissue of the affected joint(s).
The pathogenesis of rheumatoid arthritis is complex and involves cells of both innate and
adaptive immunity, a network of various cytokines and an immunoregulatory dysfunction.
An important role in the discovery of rheumatoid arthritis pathogenesis was played
by magnetic resonance imaging, which showed the disease process to extend beyond the
synovium into the bone marrow. Many studies have shown a strict correlation between the
vascularity of the synovium (assessed through the power Doppler ultrasound and magnetic
resonance examinations), bone marrow edema and the clinical, laboratory and histopathological
parameters of rheumatoid arthritis. From the current understanding of rheumatoid
arthritis, bone erosions could occur from two directions: from the joint cavity and from the
bone marrow. With power Doppler ultrasound, as well as in magnetic resonance imaging,
it is possible to visualize the well-vascularized pannus and its destructive effects on joint
structures and ligaments. In addition, the magnetic resonance study shows inflammatory
and destructive changes within the bone marrow (bone marrow edema, inflammatory cysts,
and erosions). Bone marrow edema occurs in 68–75% of patients with early rheumatoid
arthritis and is considered to be a predictor of rapid disease progression. |
| first_indexed | 2024-04-12T07:34:00Z |
| format | Article |
| id | doaj.art-b88027cd622348659464090a849aa6ff |
| institution | Directory Open Access Journal |
| issn | 2084-8404 2451-070X |
| language | English |
| last_indexed | 2024-04-12T07:34:00Z |
| publishDate | 2012-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Ultrasonography |
| spelling | doaj.art-b88027cd622348659464090a849aa6ff2022-12-22T03:42:00ZengSciendoJournal of Ultrasonography2084-84042451-070X2012-06-011249202213The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membraneIwona Sudoł‑Szopińska0Ewa Kontny1Włodzimierz Maśliński2Monika Prochorec‑Sobieszek3Brygida Kwiatkowska4Katarzyna Zaniewicz‑Kaniewska5Agnieszka Warczyńska6Zakład Radiologii, Instytut Reumatologii, Warszawa, Polska; Zakład Diagnostyki Obrazowej, Warszawski Uniwersytet Medyczny, PolskaZakład Patofizjologii, Immunologii i Anatomii Patologicznej, Instytut Reumatologii, Warszawa, PolskaZakład Patofizjologii, Immunologii i Anatomii Patologicznej, Instytut Reumatologii, Warszawa, PolskaZakład Patofizjologii, Immunologii i Anatomii Patologicznej, Instytut Reumatologii, Warszawa, Polska; Zakład Diagnostyki Hematologicznej, Instytut Hematologii i Transfuzjologii, Warszawa, PolskaOddział Wczesnej Diagnostyki, Instytut Reumatologii, Warszawa, PolskaZakład Radiologii, Instytut Reumatologii, Warszawa, PolskaZakład Radiologii, Instytut Reumatologii, Warszawa, PolskaRheumatoid arthritis is a chronic inflammatory disease with a multifactorial etiology and varied course, which in the majority of patients leads to partial disability or to permanent handicap. Its characteristic trait is a persistent inflammation of the synovial membrane and the formation of an invasive synovial tissue, called the pannus, which in time leads to destruction of the cartilage, subchondral bone tissue, and the soft tissue of the affected joint(s). The pathogenesis of rheumatoid arthritis is complex and involves cells of both innate and adaptive immunity, a network of various cytokines and an immunoregulatory dysfunction. An important role in the discovery of rheumatoid arthritis pathogenesis was played by magnetic resonance imaging, which showed the disease process to extend beyond the synovium into the bone marrow. Many studies have shown a strict correlation between the vascularity of the synovium (assessed through the power Doppler ultrasound and magnetic resonance examinations), bone marrow edema and the clinical, laboratory and histopathological parameters of rheumatoid arthritis. From the current understanding of rheumatoid arthritis, bone erosions could occur from two directions: from the joint cavity and from the bone marrow. With power Doppler ultrasound, as well as in magnetic resonance imaging, it is possible to visualize the well-vascularized pannus and its destructive effects on joint structures and ligaments. In addition, the magnetic resonance study shows inflammatory and destructive changes within the bone marrow (bone marrow edema, inflammatory cysts, and erosions). Bone marrow edema occurs in 68–75% of patients with early rheumatoid arthritis and is considered to be a predictor of rapid disease progression.http://jultrason.pl/index.php/issues/volume-12-no-49/the-pathogenesis-of-rheumatoid-arthritis-in-radiological-studies-part-i-formation-of-inflammatory-infiltrates-within-the-synovial-membrane?aid=14rheumatoid arthritispathogenesisradiographsultrasonographymagnetic resonance imagingbone marrow edema |
| spellingShingle | Iwona Sudoł‑Szopińska Ewa Kontny Włodzimierz Maśliński Monika Prochorec‑Sobieszek Brygida Kwiatkowska Katarzyna Zaniewicz‑Kaniewska Agnieszka Warczyńska The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane Journal of Ultrasonography rheumatoid arthritis pathogenesis radiographs ultrasonography magnetic resonance imaging bone marrow edema |
| title | The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane |
| title_full | The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane |
| title_fullStr | The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane |
| title_full_unstemmed | The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane |
| title_short | The pathogenesis of rheumatoid arthritis in radiological studies. Part I: Formation of inflammatory infiltrates within the synovial membrane |
| title_sort | pathogenesis of rheumatoid arthritis in radiological studies part i formation of inflammatory infiltrates within the synovial membrane |
| topic | rheumatoid arthritis pathogenesis radiographs ultrasonography magnetic resonance imaging bone marrow edema |
| url | http://jultrason.pl/index.php/issues/volume-12-no-49/the-pathogenesis-of-rheumatoid-arthritis-in-radiological-studies-part-i-formation-of-inflammatory-infiltrates-within-the-synovial-membrane?aid=14 |
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