Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study
Colorectal cancer (CRC) is a pressing global health challenge, with an estimated 1.9 million new cases in 2020. Ranking as the third most diagnosed cancer globally, CRC accounts for nearly 930,000 cancer-related deaths annually. Nectins, immunoglobulin-like adhesion molecules, are pivotal in interce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/21/15900 |
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| author | Jakub Kobecki Paweł Gajdzis Grzegorz Mazur Mariusz Chabowski |
| author_facet | Jakub Kobecki Paweł Gajdzis Grzegorz Mazur Mariusz Chabowski |
| author_sort | Jakub Kobecki |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is a pressing global health challenge, with an estimated 1.9 million new cases in 2020. Ranking as the third most diagnosed cancer globally, CRC accounts for nearly 930,000 cancer-related deaths annually. Nectins, immunoglobulin-like adhesion molecules, are pivotal in intercellular adhesion formation and cellular function regulation. Altered nectin expression patterns have been identified in various cancers. However, the intricacies of their role in cancer development and progression remain underexplored. This study aimed to evaluate the expression of specific nectins in CRC tumors, explore their association with clinicopathological factors, and ascertain their potential as prognostic indicators for CRC patients post-resection. We retrospectively analyzed the medical records of 92 CRC patients who underwent surgical treatment between 2013 and 2014. Tumor specimens were re-evaluated to determine nectin expression using immunohistochemistry. The study identified heterogeneous expressions of nectin-2, -3, and -4 in 58%, 62.6%, and 87.9% of specimens, respectively. Elevated nectin-4 expression correlated with worse 5-year and overall survival rates, presenting a negative prognostic value (HR = 4, 95% CI: 2.4–6.8, <i>p</i> < 0.001). Conversely, reduced nectin-3 expression was linked to poorer CRC prognosis (HR = 0.54; 95% CI: 0.31–0.96; <i>p</i> = 0.036). Nectin-4 expression positively correlated with elevated carcinoembryonic antigen (CEA) levels and advanced disease stages. In contrast, nectin-3 expression negatively correlated with CEA levels, tumor size, presence of distant metastases, and disease stage. Notably, tumors in the right colon were statistically more likely to express nectin-2 compared to those in the left. This study underscores the potential prognostic significance of nectins in CRC. The high prevalence of nectin-4-expressing cells offers promising avenues for further evaluation in targeted therapeutic interventions with already available agents such as PADCEV. |
| first_indexed | 2024-03-11T11:27:42Z |
| format | Article |
| id | doaj.art-b88091521cdc4fba91ae47233907ea9b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T11:27:42Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b88091521cdc4fba91ae47233907ea9b2023-11-10T15:05:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124211590010.3390/ijms242115900Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory StudyJakub Kobecki0Paweł Gajdzis1Grzegorz Mazur2Mariusz Chabowski3Department of Surgery, 4th Military Teaching Hospital, 5 Weigla Street, 50-981 Wroclaw, PolandDepartment of Pathomorphology, 4th Military Teaching Hospital, 5 Weigla Street, 50-981 Wroclaw, PolandDepartment of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, 213 Borowska Street, 50-556 Wroclaw, PolandDepartment of Surgery, 4th Military Teaching Hospital, 5 Weigla Street, 50-981 Wroclaw, PolandColorectal cancer (CRC) is a pressing global health challenge, with an estimated 1.9 million new cases in 2020. Ranking as the third most diagnosed cancer globally, CRC accounts for nearly 930,000 cancer-related deaths annually. Nectins, immunoglobulin-like adhesion molecules, are pivotal in intercellular adhesion formation and cellular function regulation. Altered nectin expression patterns have been identified in various cancers. However, the intricacies of their role in cancer development and progression remain underexplored. This study aimed to evaluate the expression of specific nectins in CRC tumors, explore their association with clinicopathological factors, and ascertain their potential as prognostic indicators for CRC patients post-resection. We retrospectively analyzed the medical records of 92 CRC patients who underwent surgical treatment between 2013 and 2014. Tumor specimens were re-evaluated to determine nectin expression using immunohistochemistry. The study identified heterogeneous expressions of nectin-2, -3, and -4 in 58%, 62.6%, and 87.9% of specimens, respectively. Elevated nectin-4 expression correlated with worse 5-year and overall survival rates, presenting a negative prognostic value (HR = 4, 95% CI: 2.4–6.8, <i>p</i> < 0.001). Conversely, reduced nectin-3 expression was linked to poorer CRC prognosis (HR = 0.54; 95% CI: 0.31–0.96; <i>p</i> = 0.036). Nectin-4 expression positively correlated with elevated carcinoembryonic antigen (CEA) levels and advanced disease stages. In contrast, nectin-3 expression negatively correlated with CEA levels, tumor size, presence of distant metastases, and disease stage. Notably, tumors in the right colon were statistically more likely to express nectin-2 compared to those in the left. This study underscores the potential prognostic significance of nectins in CRC. The high prevalence of nectin-4-expressing cells offers promising avenues for further evaluation in targeted therapeutic interventions with already available agents such as PADCEV.https://www.mdpi.com/1422-0067/24/21/15900colorectal canceradhesion moleculesnectinprognostic factors |
| spellingShingle | Jakub Kobecki Paweł Gajdzis Grzegorz Mazur Mariusz Chabowski Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study International Journal of Molecular Sciences colorectal cancer adhesion molecules nectin prognostic factors |
| title | Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study |
| title_full | Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study |
| title_fullStr | Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study |
| title_full_unstemmed | Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study |
| title_short | Prognostic Potential of Nectin Expressions in Colorectal Cancer: An Exploratory Study |
| title_sort | prognostic potential of nectin expressions in colorectal cancer an exploratory study |
| topic | colorectal cancer adhesion molecules nectin prognostic factors |
| url | https://www.mdpi.com/1422-0067/24/21/15900 |
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