<i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review
(1) <b>Background:</b> In recent years, a global epidemiological shift in candidemia has been observed, marked by the emergence of resistant non-albicans Candida species. <i>Candida auris</i>, in particular, has become a significant global concern, causing infections in both...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/6/1586 |
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| author | Rozeta Sokou Alexia Eleftheria Palioura Paschalia Kopanou Taliaka Aikaterini Konstantinidi Andreas G. Tsantes Daniele Piovani Konstantina A. Tsante Eleni A. Gounari Zoi Iliodromiti Theodora Boutsikou Argirios E. Tsantes Stefanos Bonovas Nicoletta Iacovidou |
| author_facet | Rozeta Sokou Alexia Eleftheria Palioura Paschalia Kopanou Taliaka Aikaterini Konstantinidi Andreas G. Tsantes Daniele Piovani Konstantina A. Tsante Eleni A. Gounari Zoi Iliodromiti Theodora Boutsikou Argirios E. Tsantes Stefanos Bonovas Nicoletta Iacovidou |
| author_sort | Rozeta Sokou |
| collection | DOAJ |
| description | (1) <b>Background:</b> In recent years, a global epidemiological shift in candidemia has been observed, marked by the emergence of resistant non-albicans Candida species. <i>Candida auris</i>, in particular, has become a significant global concern, causing infections in both pediatric and adult populations within healthcare settings. Despite its widespread impact, there is a limited understanding of the clinical course and transmission dynamics of neonatal systemic Candida auris infections, hindering effective prevention and management. This study focused on the epidemiologic data, the clinical presentation, risk factors, and outcome of <i>C. auris</i> infection in neonatal population. (2) <b>Methods</b>: A systematic review of the literature using PubMed and Scopus databases until December 2023 was conducted. (3) <b>Results</b>: A total of 24 relevant studies were identified, encompassing 476 documented cases of <i>Candida auris</i> infection in neonates. Prematurity emerged as a primary risk factor, alongside total parenteral nutrition, central line insertion, mechanical ventilation, and prior broad-spectrum antibiotic use. The mortality rate reached approximately 42%, with therapeutic details sparingly reported in 12% of cases. Treatment strategies varied, with amphotericin B predominantly used as monotherapy, while combination antifungal agents were used in 44% of cases. Notably, 97.4% of cases exhibited fluconazole resistance, and 67.1% showed resistance to amphotericin B. Limited data were available on resistance to other antifungal agents. (4) <b>Conclusions</b>: Despite the rarity of neonatal <i>Candida auris</i> infections, their global occurrence necessitates comprehensive preparedness in patient care. A deeper understanding of <i>Candida auris</i> pathogenesis is crucial for developing effective strategies to control and prevent neonatal infections caused by this pathogen. |
| first_indexed | 2024-04-24T18:09:30Z |
| format | Article |
| id | doaj.art-b88206792a324d528e0deef61a088bf7 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T18:09:30Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b88206792a324d528e0deef61a088bf72024-03-27T13:47:46ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01136158610.3390/jcm13061586<i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic ReviewRozeta Sokou0Alexia Eleftheria Palioura1Paschalia Kopanou Taliaka2Aikaterini Konstantinidi3Andreas G. Tsantes4Daniele Piovani5Konstantina A. Tsante6Eleni A. Gounari7Zoi Iliodromiti8Theodora Boutsikou9Argirios E. Tsantes10Stefanos Bonovas11Nicoletta Iacovidou12Neonatal Intensive Care Unit, “Agios Panteleimon” General Hospital of Nikea, 18454 Piraeus, GreeceNeonatal Intensive Care Unit, “Agios Panteleimon” General Hospital of Nikea, 18454 Piraeus, GreeceNeonatal Intensive Care Unit, “Agios Panteleimon” General Hospital of Nikea, 18454 Piraeus, GreeceNeonatal Intensive Care Unit, “Agios Panteleimon” General Hospital of Nikea, 18454 Piraeus, GreeceMicrobiology Department, “Saint Savvas” Oncology Hospital, 11522 Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, ItalyLaboratory of Haematology and Blood Bank Unit, “Attiko” Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, GreeceEast Sussex Hospitals NHS Trust, Hastings TN37 7PT, UKNeonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, GreeceNeonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, GreeceLaboratory of Haematology and Blood Bank Unit, “Attiko” Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, ItalyNeonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece(1) <b>Background:</b> In recent years, a global epidemiological shift in candidemia has been observed, marked by the emergence of resistant non-albicans Candida species. <i>Candida auris</i>, in particular, has become a significant global concern, causing infections in both pediatric and adult populations within healthcare settings. Despite its widespread impact, there is a limited understanding of the clinical course and transmission dynamics of neonatal systemic Candida auris infections, hindering effective prevention and management. This study focused on the epidemiologic data, the clinical presentation, risk factors, and outcome of <i>C. auris</i> infection in neonatal population. (2) <b>Methods</b>: A systematic review of the literature using PubMed and Scopus databases until December 2023 was conducted. (3) <b>Results</b>: A total of 24 relevant studies were identified, encompassing 476 documented cases of <i>Candida auris</i> infection in neonates. Prematurity emerged as a primary risk factor, alongside total parenteral nutrition, central line insertion, mechanical ventilation, and prior broad-spectrum antibiotic use. The mortality rate reached approximately 42%, with therapeutic details sparingly reported in 12% of cases. Treatment strategies varied, with amphotericin B predominantly used as monotherapy, while combination antifungal agents were used in 44% of cases. Notably, 97.4% of cases exhibited fluconazole resistance, and 67.1% showed resistance to amphotericin B. Limited data were available on resistance to other antifungal agents. (4) <b>Conclusions</b>: Despite the rarity of neonatal <i>Candida auris</i> infections, their global occurrence necessitates comprehensive preparedness in patient care. A deeper understanding of <i>Candida auris</i> pathogenesis is crucial for developing effective strategies to control and prevent neonatal infections caused by this pathogen.https://www.mdpi.com/2077-0383/13/6/1586<i>Candida auris</i>neonatescandida infection |
| spellingShingle | Rozeta Sokou Alexia Eleftheria Palioura Paschalia Kopanou Taliaka Aikaterini Konstantinidi Andreas G. Tsantes Daniele Piovani Konstantina A. Tsante Eleni A. Gounari Zoi Iliodromiti Theodora Boutsikou Argirios E. Tsantes Stefanos Bonovas Nicoletta Iacovidou <i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review Journal of Clinical Medicine <i>Candida auris</i> neonates candida infection |
| title | <i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review |
| title_full | <i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review |
| title_fullStr | <i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review |
| title_full_unstemmed | <i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review |
| title_short | <i>Candida auris</i> Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review |
| title_sort | i candida auris i infection a rapidly emerging threat in the neonatal intensive care units a systematic review |
| topic | <i>Candida auris</i> neonates candida infection |
| url | https://www.mdpi.com/2077-0383/13/6/1586 |
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