Review: Progress in producing chimeric ungulate livestock for agricultural applications
The progress made in recent years in the derivation and culture of pluripotent stem cells from farm animals opens up the possibility of creating livestock chimeras. Chimeras producing gametes exclusively derived from elite donor stem cells could pass superior genetics on to the next generation and t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Animal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S175173112300099X |
| _version_ | 1797745280268894208 |
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| author | Alba V. Ledesma Maci L. Mueller Alison L. Van Eenennaam |
| author_facet | Alba V. Ledesma Maci L. Mueller Alison L. Van Eenennaam |
| author_sort | Alba V. Ledesma |
| collection | DOAJ |
| description | The progress made in recent years in the derivation and culture of pluripotent stem cells from farm animals opens up the possibility of creating livestock chimeras. Chimeras producing gametes exclusively derived from elite donor stem cells could pass superior genetics on to the next generation and thereby reduce the genetic lag that typically exists between the elite breeding sector and the commercial production sector, especially for industries like beef and sheep where genetics is commonly disseminated through natural service mating. Chimeras carrying germ cells generated from genome-edited or genetically engineered pluripotent stem cells could further disseminate useful genomic alterations such as climate adaptation, animal welfare improvements, the repair of deleterious genetic conditions, and/or the elimination of undesired traits such as disease susceptibility to the next generation. Despite the successful production of chimeras with germ cells generated from pluripotent donor stem cells injected into preimplantation-stage blastocysts in model species, there are no documented cases of this occurring in livestock. Here, we review the literature on the derivation of pluripotent stem cells from ungulates, and progress in the production of chimeric ungulate livestock for agricultural applications, drawing on insights from studies done in model species, and discuss future possibilities of this fast-moving and developing field. Aside from the technical aspects, the consistency of the regulatory approach taken by different jurisdictions towards chimeric ungulate livestock with germ cells generated from pluripotent stem cells and their progeny will be an important determinant of breeding industry uptake and adoption in animal agriculture. |
| first_indexed | 2024-03-12T15:21:08Z |
| format | Article |
| id | doaj.art-b88324decc1b44b7aa5e62a651b65599 |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-03-12T15:21:08Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-b88324decc1b44b7aa5e62a651b655992023-08-11T05:32:32ZengElsevierAnimal1751-73112023-05-0117100803Review: Progress in producing chimeric ungulate livestock for agricultural applicationsAlba V. Ledesma0Maci L. Mueller1Alison L. Van Eenennaam2Department of Animal Science, University of California, One Shields Avenue, Davis, CA 95616, USADepartment of Animal Science, University of California, One Shields Avenue, Davis, CA 95616, USACorresponding author.; Department of Animal Science, University of California, One Shields Avenue, Davis, CA 95616, USAThe progress made in recent years in the derivation and culture of pluripotent stem cells from farm animals opens up the possibility of creating livestock chimeras. Chimeras producing gametes exclusively derived from elite donor stem cells could pass superior genetics on to the next generation and thereby reduce the genetic lag that typically exists between the elite breeding sector and the commercial production sector, especially for industries like beef and sheep where genetics is commonly disseminated through natural service mating. Chimeras carrying germ cells generated from genome-edited or genetically engineered pluripotent stem cells could further disseminate useful genomic alterations such as climate adaptation, animal welfare improvements, the repair of deleterious genetic conditions, and/or the elimination of undesired traits such as disease susceptibility to the next generation. Despite the successful production of chimeras with germ cells generated from pluripotent donor stem cells injected into preimplantation-stage blastocysts in model species, there are no documented cases of this occurring in livestock. Here, we review the literature on the derivation of pluripotent stem cells from ungulates, and progress in the production of chimeric ungulate livestock for agricultural applications, drawing on insights from studies done in model species, and discuss future possibilities of this fast-moving and developing field. Aside from the technical aspects, the consistency of the regulatory approach taken by different jurisdictions towards chimeric ungulate livestock with germ cells generated from pluripotent stem cells and their progeny will be an important determinant of breeding industry uptake and adoption in animal agriculture.http://www.sciencedirect.com/science/article/pii/S175173112300099XChimeraGermlinePluripotencyStem CellsUngulate |
| spellingShingle | Alba V. Ledesma Maci L. Mueller Alison L. Van Eenennaam Review: Progress in producing chimeric ungulate livestock for agricultural applications Animal Chimera Germline Pluripotency Stem Cells Ungulate |
| title | Review: Progress in producing chimeric ungulate livestock for agricultural applications |
| title_full | Review: Progress in producing chimeric ungulate livestock for agricultural applications |
| title_fullStr | Review: Progress in producing chimeric ungulate livestock for agricultural applications |
| title_full_unstemmed | Review: Progress in producing chimeric ungulate livestock for agricultural applications |
| title_short | Review: Progress in producing chimeric ungulate livestock for agricultural applications |
| title_sort | review progress in producing chimeric ungulate livestock for agricultural applications |
| topic | Chimera Germline Pluripotency Stem Cells Ungulate |
| url | http://www.sciencedirect.com/science/article/pii/S175173112300099X |
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