Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes
Conservative surgery is the preferred treatment in the management of breast cancer followed by adjuvant whole-breast irradiation. Since the tumor bed is the main site of relapse, boost doses are conveniently administered according to risk factors for local relapse to increase the efficacy of the tre...
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Format: | Article |
Language: | English |
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MDPI AG
2023-08-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/15/16/4025 |
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author | Javier Sanz Arantxa Eraso Reyes Ibáñez Rachel Williams Manuel Algara |
author_facet | Javier Sanz Arantxa Eraso Reyes Ibáñez Rachel Williams Manuel Algara |
author_sort | Javier Sanz |
collection | DOAJ |
description | Conservative surgery is the preferred treatment in the management of breast cancer followed by adjuvant whole-breast irradiation. Since the tumor bed is the main site of relapse, boost doses are conveniently administered according to risk factors for local relapse to increase the efficacy of the treatment. The benefit of a radiation boost is well established and it can be performed by several techniques like brachytherapy, external radiation or intraoperative radiotherapy. Greater precision in localizing the tumor cavity, immediacy and increased biological response are the main advantages of intraoperative boost irradiation. This modality of treatment can be performed by means of mobile electron accelerators or low-photon X-ray devices. There is a lot of research and some published series analyzing the results of the use of an intraoperative boost as an adjuvant treatment, after neoadjuvant systemic therapy and in combination with some reconstructive surgeries. This review discusses advantages of intraoperative radiotherapy and presents the main results of a boost in terms of local control, survival, tolerance and cosmesis. |
first_indexed | 2024-03-11T00:04:45Z |
format | Article |
id | doaj.art-b883850c3edf418899547c4c3d111980 |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-11T00:04:45Z |
publishDate | 2023-08-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-b883850c3edf418899547c4c3d1119802023-11-19T00:32:03ZengMDPI AGCancers2072-66942023-08-011516402510.3390/cancers15164025Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and OutcomesJavier Sanz0Arantxa Eraso1Reyes Ibáñez2Rachel Williams3Manuel Algara4Radiation Oncology Department, Hospital del Mar Barcelona, 08003 Barcelona, SpainRadiation Oncology Department, Institut Català d’Oncologia, Hospital Trueta, 17007 Girona, SpainRadiation Oncology Department, Hospital Universitario Miguel Servet, 50009 Zaragoza, SpainCollege of Liberal Arts, Texas A&M University, College Station, TX 77843, USARadiation Oncology Department, Hospital del Mar Barcelona, 08003 Barcelona, SpainConservative surgery is the preferred treatment in the management of breast cancer followed by adjuvant whole-breast irradiation. Since the tumor bed is the main site of relapse, boost doses are conveniently administered according to risk factors for local relapse to increase the efficacy of the treatment. The benefit of a radiation boost is well established and it can be performed by several techniques like brachytherapy, external radiation or intraoperative radiotherapy. Greater precision in localizing the tumor cavity, immediacy and increased biological response are the main advantages of intraoperative boost irradiation. This modality of treatment can be performed by means of mobile electron accelerators or low-photon X-ray devices. There is a lot of research and some published series analyzing the results of the use of an intraoperative boost as an adjuvant treatment, after neoadjuvant systemic therapy and in combination with some reconstructive surgeries. This review discusses advantages of intraoperative radiotherapy and presents the main results of a boost in terms of local control, survival, tolerance and cosmesis.https://www.mdpi.com/2072-6694/15/16/4025breast cancerconservative treatmentwhole breast irradiation (WBI)tumor bed boostintraoperative radiotherapyoutcomes |
spellingShingle | Javier Sanz Arantxa Eraso Reyes Ibáñez Rachel Williams Manuel Algara Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes Cancers breast cancer conservative treatment whole breast irradiation (WBI) tumor bed boost intraoperative radiotherapy outcomes |
title | Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes |
title_full | Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes |
title_fullStr | Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes |
title_full_unstemmed | Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes |
title_short | Tumor Bed Boost Radiotherapy in the Conservative Treatment of Breast Cancer: A Review of Intra-Operative Techniques and Outcomes |
title_sort | tumor bed boost radiotherapy in the conservative treatment of breast cancer a review of intra operative techniques and outcomes |
topic | breast cancer conservative treatment whole breast irradiation (WBI) tumor bed boost intraoperative radiotherapy outcomes |
url | https://www.mdpi.com/2072-6694/15/16/4025 |
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