Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study
Objectives This study aimed to elicit preferences for psoriasis treatment features and to test for preference heterogeneity across groups of respondents. Materials and methods A discrete-choice experiment was employed to elicit preferences of patients with plaque psoriasis in multiple countries. The...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-04-01
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| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2020.1869145 |
| _version_ | 1797683568708681728 |
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| author | Marco Boeri Daniel Saure Christopher Schuster Julie Hill Mariana Guerreiro Kathleen Klein Brett Hauber |
| author_facet | Marco Boeri Daniel Saure Christopher Schuster Julie Hill Mariana Guerreiro Kathleen Klein Brett Hauber |
| author_sort | Marco Boeri |
| collection | DOAJ |
| description | Objectives This study aimed to elicit preferences for psoriasis treatment features and to test for preference heterogeneity across groups of respondents. Materials and methods A discrete-choice experiment was employed to elicit preferences of patients with plaque psoriasis in multiple countries. The survey instrument included a series of choice questions between three hypothetical treatments, each characterized by varying levels of six attributes (namely, lesion reduction, risk of impairing side effects, time to reach results, mode and frequency of administration, itching reduction, and side effects). Random parameters logit was used to model the data. Results were compared across a total of 18 subgroup sets. Results The data analysis from 1,123 respondents showed that, on average, respondents receive more utility gain from higher levels of lesion reduction and lower risks of impairing side effects than changes in other attributes included in the study. Systematic differences were detected for 13 sets; the most pronounced differences were observed based on disease severity, nail psoriasis, biologic experience, and quality-of-life scores. Conclusion These many sources of preference heterogeneity identified by our analysis suggest that to improve patient satisfaction and, probably, adherence and persistence, clinicians should discuss options with patients when prescribing their treatment. |
| first_indexed | 2024-03-12T00:16:15Z |
| format | Article |
| id | doaj.art-b88419a9a0794eadb9228125cb30910d |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:16:15Z |
| publishDate | 2022-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-b88419a9a0794eadb9228125cb30910d2023-09-15T14:28:49ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532022-04-013331598160510.1080/09546634.2020.18691451869145Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry studyMarco Boeri0Daniel Saure1Christopher Schuster2Julie Hill3Mariana Guerreiro4Kathleen Klein5Brett Hauber6RTI Health Solutions, Health Preference AssessmentEli Lilly and CompanyEli Lilly and CompanyEli Lilly and CompanyEli Lilly and CompanyRTI Health Solutions, Health Preference Assessment, Research Triangle ParkRTI Health Solutions, Health Preference Assessment, Research Triangle ParkObjectives This study aimed to elicit preferences for psoriasis treatment features and to test for preference heterogeneity across groups of respondents. Materials and methods A discrete-choice experiment was employed to elicit preferences of patients with plaque psoriasis in multiple countries. The survey instrument included a series of choice questions between three hypothetical treatments, each characterized by varying levels of six attributes (namely, lesion reduction, risk of impairing side effects, time to reach results, mode and frequency of administration, itching reduction, and side effects). Random parameters logit was used to model the data. Results were compared across a total of 18 subgroup sets. Results The data analysis from 1,123 respondents showed that, on average, respondents receive more utility gain from higher levels of lesion reduction and lower risks of impairing side effects than changes in other attributes included in the study. Systematic differences were detected for 13 sets; the most pronounced differences were observed based on disease severity, nail psoriasis, biologic experience, and quality-of-life scores. Conclusion These many sources of preference heterogeneity identified by our analysis suggest that to improve patient satisfaction and, probably, adherence and persistence, clinicians should discuss options with patients when prescribing their treatment.http://dx.doi.org/10.1080/09546634.2020.1869145psoriasis treatmentbiologicstopicalpatient preference heterogeneitydiscrete choice experimentsubgroup analysis |
| spellingShingle | Marco Boeri Daniel Saure Christopher Schuster Julie Hill Mariana Guerreiro Kathleen Klein Brett Hauber Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study Journal of Dermatological Treatment psoriasis treatment biologics topical patient preference heterogeneity discrete choice experiment subgroup analysis |
| title | Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study |
| title_full | Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study |
| title_fullStr | Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study |
| title_full_unstemmed | Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study |
| title_short | Impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features: Results from a discrete-choice experiment in a multicountry study |
| title_sort | impact of clinical and demographic characteristics on patient preferences for psoriasis treatment features results from a discrete choice experiment in a multicountry study |
| topic | psoriasis treatment biologics topical patient preference heterogeneity discrete choice experiment subgroup analysis |
| url | http://dx.doi.org/10.1080/09546634.2020.1869145 |
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