Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits
Phosphoglycerate mutase (PGAM2) catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate and releases energy during glycolysis in muscle tissues. PGAM2 has been considered as a candidate gene to influence growth, development, and carcass traits in livestock. The aim of this study was t...
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| Format: | Article |
| Language: | English |
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Czech Academy of Agricultural Sciences
2015-03-01
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| Series: | Czech Journal of Animal Science |
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| Online Access: | https://cjas.agriculturejournals.cz/artkey/cjs-201503-0007_association-of-a-synonymous-mutation-of-the-pgam2-gene-and-growth-traits-in-rabbits.php |
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| author | Z.-L. Wu S.-Y. Chen X.-B. Jia S.-J. Lai |
| author_facet | Z.-L. Wu S.-Y. Chen X.-B. Jia S.-J. Lai |
| author_sort | Z.-L. Wu |
| collection | DOAJ |
| description | Phosphoglycerate mutase (PGAM2) catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate and releases energy during glycolysis in muscle tissues. PGAM2 has been considered as a candidate gene to influence growth, development, and carcass traits in livestock. The aim of this study was to investigate the association between polymorphisms of PGAM2 and growth traits in rabbits. Three single nucleotide polymorphisms (SNPs) were identified by direct sequencing in 20 random individuals from three breeds, including c.-10C>T, c.195C>T, and c.414+17C>T. The c.195C>T was genotyped by PCR-RFLP in a total of 222 rabbits of three breeds (Tianfu black, 53 animals; Ira, 91 animals; Champagne, 78 animals). The average allele frequency among the breeds was 0.52 for allele T and 0.48 for C. The heterozygosity and effective number of alleles were 0.4992 and 1.996, respectively. The association results revealed the CT genotype of c.195C>T was associated significantly (P < 0.05) with greater body weight at 84 days of age (BW84) and with average daily weight gain (ADG). However, association of the genotypes with other production traits was not observed. The results of this study suggested PGAM2 is one of the candidate genes affecting BW84 and ADG in the rabbit. |
| first_indexed | 2024-04-10T08:26:29Z |
| format | Article |
| id | doaj.art-b886de234a5843d59570f5b39cc4f6b1 |
| institution | Directory Open Access Journal |
| issn | 1212-1819 1805-9309 |
| language | English |
| last_indexed | 2024-04-10T08:26:29Z |
| publishDate | 2015-03-01 |
| publisher | Czech Academy of Agricultural Sciences |
| record_format | Article |
| series | Czech Journal of Animal Science |
| spelling | doaj.art-b886de234a5843d59570f5b39cc4f6b12023-02-23T03:33:18ZengCzech Academy of Agricultural SciencesCzech Journal of Animal Science1212-18191805-93092015-03-0160313914410.17221/8079-CJAScjs-201503-0007Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbitsZ.-L. Wu0S.-Y. Chen1X.-B. Jia2S.-J. Lai3Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Sichuan, P.R. ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Sichuan, P.R. ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Sichuan, P.R. ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Sichuan, P.R. ChinaPhosphoglycerate mutase (PGAM2) catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate and releases energy during glycolysis in muscle tissues. PGAM2 has been considered as a candidate gene to influence growth, development, and carcass traits in livestock. The aim of this study was to investigate the association between polymorphisms of PGAM2 and growth traits in rabbits. Three single nucleotide polymorphisms (SNPs) were identified by direct sequencing in 20 random individuals from three breeds, including c.-10C>T, c.195C>T, and c.414+17C>T. The c.195C>T was genotyped by PCR-RFLP in a total of 222 rabbits of three breeds (Tianfu black, 53 animals; Ira, 91 animals; Champagne, 78 animals). The average allele frequency among the breeds was 0.52 for allele T and 0.48 for C. The heterozygosity and effective number of alleles were 0.4992 and 1.996, respectively. The association results revealed the CT genotype of c.195C>T was associated significantly (P < 0.05) with greater body weight at 84 days of age (BW84) and with average daily weight gain (ADG). However, association of the genotypes with other production traits was not observed. The results of this study suggested PGAM2 is one of the candidate genes affecting BW84 and ADG in the rabbit.https://cjas.agriculturejournals.cz/artkey/cjs-201503-0007_association-of-a-synonymous-mutation-of-the-pgam2-gene-and-growth-traits-in-rabbits.phpsnpsbody weightaverage daily weight gainassociation analysiscandidate gene |
| spellingShingle | Z.-L. Wu S.-Y. Chen X.-B. Jia S.-J. Lai Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits Czech Journal of Animal Science snps body weight average daily weight gain association analysis candidate gene |
| title | Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits |
| title_full | Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits |
| title_fullStr | Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits |
| title_full_unstemmed | Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits |
| title_short | Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits |
| title_sort | association of a synonymous mutation of the pgam2 gene and growth traits in rabbits |
| topic | snps body weight average daily weight gain association analysis candidate gene |
| url | https://cjas.agriculturejournals.cz/artkey/cjs-201503-0007_association-of-a-synonymous-mutation-of-the-pgam2-gene-and-growth-traits-in-rabbits.php |
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