Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy
Abstract Photothermal therapy (PTT) has emerged as a promising cancer therapeutic modality with high therapeutic specificity, however, its therapeutic effectiveness is limited by available high‐efficiency photothermal agents (PTAs), especially in the second near‐infrared (NIR‐II) biowindow. Here, ba...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.201902576 |
| _version_ | 1819063914299654144 |
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| author | Qiuhong Zhang Qiangbing Guo Qian Chen Xiaoxu Zhao Stephen J. Pennycook Hangrong Chen |
| author_facet | Qiuhong Zhang Qiangbing Guo Qian Chen Xiaoxu Zhao Stephen J. Pennycook Hangrong Chen |
| author_sort | Qiuhong Zhang |
| collection | DOAJ |
| description | Abstract Photothermal therapy (PTT) has emerged as a promising cancer therapeutic modality with high therapeutic specificity, however, its therapeutic effectiveness is limited by available high‐efficiency photothermal agents (PTAs), especially in the second near‐infrared (NIR‐II) biowindow. Here, based on facile liquid‐exfoliated FePS3 nanosheets, a highly efficient NIR‐II PTA with its photothermal conversion efficiency of up to 43.3% is demonstrated, which is among the highest reported levels in typical PTAs. More importantly, such Fe‐based 2D nanosheets also show superior Fenton catalytic activity facilitated by their ultrahigh specific surface area, simultaneously enabling cancer chemodynamic therapy (CDT). Impressively, the efficiency of CDT could be further remarkably enhanced by its photothermal effect, leading to cancer synergistic PTT/CDT. Both in vitro and in vivo studies reveal a highly efficient tumor ablation under NIR‐II light irradiation. This work provides a paradigm for cancer CDT and PTT in the NIR‐II biowindow via a single 2D nanoplatform with desired therapeutic effect. Furthermore, with additional possibilities for magnetic resonance imaging, photoacoustic tomography, as well as drug loading, this Fe‐based 2D material could potentially serve as a 2D “all‐in‐one” theranostic nanoplatform. |
| first_indexed | 2024-12-21T15:22:14Z |
| format | Article |
| id | doaj.art-b889f31418a14c8d9eb6962f6baf18df |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-21T15:22:14Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-b889f31418a14c8d9eb6962f6baf18df2022-12-21T18:59:01ZengWileyAdvanced Science2198-38442020-04-0177n/an/a10.1002/advs.201902576Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic TherapyQiuhong Zhang0Qiangbing Guo1Qian Chen2Xiaoxu Zhao3Stephen J. Pennycook4Hangrong Chen5State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaDepartment of Materials Science and Engineering National University of Singapore Singapore 117575 SingaporeState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaDepartment of Materials Science and Engineering National University of Singapore Singapore 117575 SingaporeDepartment of Materials Science and Engineering National University of Singapore Singapore 117575 SingaporeState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. ChinaAbstract Photothermal therapy (PTT) has emerged as a promising cancer therapeutic modality with high therapeutic specificity, however, its therapeutic effectiveness is limited by available high‐efficiency photothermal agents (PTAs), especially in the second near‐infrared (NIR‐II) biowindow. Here, based on facile liquid‐exfoliated FePS3 nanosheets, a highly efficient NIR‐II PTA with its photothermal conversion efficiency of up to 43.3% is demonstrated, which is among the highest reported levels in typical PTAs. More importantly, such Fe‐based 2D nanosheets also show superior Fenton catalytic activity facilitated by their ultrahigh specific surface area, simultaneously enabling cancer chemodynamic therapy (CDT). Impressively, the efficiency of CDT could be further remarkably enhanced by its photothermal effect, leading to cancer synergistic PTT/CDT. Both in vitro and in vivo studies reveal a highly efficient tumor ablation under NIR‐II light irradiation. This work provides a paradigm for cancer CDT and PTT in the NIR‐II biowindow via a single 2D nanoplatform with desired therapeutic effect. Furthermore, with additional possibilities for magnetic resonance imaging, photoacoustic tomography, as well as drug loading, this Fe‐based 2D material could potentially serve as a 2D “all‐in‐one” theranostic nanoplatform.https://doi.org/10.1002/advs.201902576Fenton agentFePS3 nanosheetsNIR‐II biowindowphotothermal agentsreactive oxygen species |
| spellingShingle | Qiuhong Zhang Qiangbing Guo Qian Chen Xiaoxu Zhao Stephen J. Pennycook Hangrong Chen Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy Advanced Science Fenton agent FePS3 nanosheets NIR‐II biowindow photothermal agents reactive oxygen species |
| title | Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy |
| title_full | Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy |
| title_fullStr | Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy |
| title_full_unstemmed | Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy |
| title_short | Highly Efficient 2D NIR‐II Photothermal Agent with Fenton Catalytic Activity for Cancer Synergistic Photothermal–Chemodynamic Therapy |
| title_sort | highly efficient 2d nir ii photothermal agent with fenton catalytic activity for cancer synergistic photothermal chemodynamic therapy |
| topic | Fenton agent FePS3 nanosheets NIR‐II biowindow photothermal agents reactive oxygen species |
| url | https://doi.org/10.1002/advs.201902576 |
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