Simvastatin Reduces Neutrophils Infiltration Into Brain Parenchyma After Intracerebral Hemorrhage via Regulating Peripheral Neutrophils Apoptosis

Simvastatin Reduces Neutrophils Infiltration Into Brain Parenchyma After Intracerebral Hemorrhage via Regulating Peripheral Neutrophils Apoptosis

Statins, known for their lipid-lowering effects, also have immunomodulatory properties. This study aims to examine whether systematic simvastatin administration could decrease polymorphonuclear neutrophils (PMNs) infiltration into brain tissue, as well as alleviate neuroinflammation in a rat model o...

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Bibliographic Details
Main Authors: Jianbo Zhang, Xia Shi, Na Hao, Zhi Chen, Linjie Wei, Liang Tan, Yujie Chen, Hua Feng, Qianwei Chen, Gang Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Neuroscience
Subjects:
intracerebral hemorrhage
statins
polymorphonuclear neutrophils
apoptosis
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00977/full

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