Mitochondrial Cation Signalling in the Control of Inflammatory Processes
Mitochondria are the bioenergetic organelles responsible for the maintenance of cellular homeostasis and have also been found to be associated with inflammation. They are necessary to induce and maintain innate and adaptive immune cell responses, acting as signalling platforms and mediators in effec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/23/16724 |
| _version_ | 1797400135158726656 |
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| author | Pampa Pain Francesca Spinelli Gaia Gherardi |
| author_facet | Pampa Pain Francesca Spinelli Gaia Gherardi |
| author_sort | Pampa Pain |
| collection | DOAJ |
| description | Mitochondria are the bioenergetic organelles responsible for the maintenance of cellular homeostasis and have also been found to be associated with inflammation. They are necessary to induce and maintain innate and adaptive immune cell responses, acting as signalling platforms and mediators in effector responses. These organelles are also known to play a pivotal role in cation homeostasis as well, which regulates the inflammatory responses through the modulation of these cation channels. In particular, this review focuses on mitochondrial Ca<sup>2+</sup> and K<sup>+</sup> fluxes in the regulation of inflammatory response. Nevertheless, this review aims to understand the interplay of these inflammation inducers and pathophysiological conditions. In detail, we discuss some examples of chronic inflammation such as lung, bowel, and metabolic inflammatory diseases caused by a persistent activation of the innate immune response due to a dysregulation of mitochondrial cation homeostasis. |
| first_indexed | 2024-03-09T01:50:11Z |
| format | Article |
| id | doaj.art-b88cc04a8a0642658519a3bb6cdc7728 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T01:50:11Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b88cc04a8a0642658519a3bb6cdc77282023-12-08T15:16:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-11-0124231672410.3390/ijms242316724Mitochondrial Cation Signalling in the Control of Inflammatory ProcessesPampa Pain0Francesca Spinelli1Gaia Gherardi2Department of Biomedical Sciences, University of Padova, 35131 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35131 Padova, ItalyDepartment of Biomedical Sciences, University of Padova, 35131 Padova, ItalyMitochondria are the bioenergetic organelles responsible for the maintenance of cellular homeostasis and have also been found to be associated with inflammation. They are necessary to induce and maintain innate and adaptive immune cell responses, acting as signalling platforms and mediators in effector responses. These organelles are also known to play a pivotal role in cation homeostasis as well, which regulates the inflammatory responses through the modulation of these cation channels. In particular, this review focuses on mitochondrial Ca<sup>2+</sup> and K<sup>+</sup> fluxes in the regulation of inflammatory response. Nevertheless, this review aims to understand the interplay of these inflammation inducers and pathophysiological conditions. In detail, we discuss some examples of chronic inflammation such as lung, bowel, and metabolic inflammatory diseases caused by a persistent activation of the innate immune response due to a dysregulation of mitochondrial cation homeostasis.https://www.mdpi.com/1422-0067/24/23/16724mitochondrial Ca<sup>2+</sup> uptakeinflammationmitochondrial K<sup>+</sup> flux |
| spellingShingle | Pampa Pain Francesca Spinelli Gaia Gherardi Mitochondrial Cation Signalling in the Control of Inflammatory Processes International Journal of Molecular Sciences mitochondrial Ca<sup>2+</sup> uptake inflammation mitochondrial K<sup>+</sup> flux |
| title | Mitochondrial Cation Signalling in the Control of Inflammatory Processes |
| title_full | Mitochondrial Cation Signalling in the Control of Inflammatory Processes |
| title_fullStr | Mitochondrial Cation Signalling in the Control of Inflammatory Processes |
| title_full_unstemmed | Mitochondrial Cation Signalling in the Control of Inflammatory Processes |
| title_short | Mitochondrial Cation Signalling in the Control of Inflammatory Processes |
| title_sort | mitochondrial cation signalling in the control of inflammatory processes |
| topic | mitochondrial Ca<sup>2+</sup> uptake inflammation mitochondrial K<sup>+</sup> flux |
| url | https://www.mdpi.com/1422-0067/24/23/16724 |
| work_keys_str_mv | AT pampapain mitochondrialcationsignallinginthecontrolofinflammatoryprocesses AT francescaspinelli mitochondrialcationsignallinginthecontrolofinflammatoryprocesses AT gaiagherardi mitochondrialcationsignallinginthecontrolofinflammatoryprocesses |