Electric field computation and measurements in the electroporation of inhomogeneous samples
In clinical treatments of a class of tumors, e.g. skin tumors, the drug uptake of tumor tissue is helped by means of a pulsed electric field, which permeabilizes the cell membranes. This technique, which is called electroporation, exploits the conductivity of the tissues: however, the tumor tissue c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-12-01
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| Series: | Open Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/phys-2017-0092 |
| _version_ | 1831581402215219200 |
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| author | Bernardis Alessia Bullo Marco Campana Luca Giovanni Di Barba Paolo Dughiero Fabrizio Forzan Michele Mognaschi Maria Evelina Sgarbossa Paolo Sieni Elisabetta |
| author_facet | Bernardis Alessia Bullo Marco Campana Luca Giovanni Di Barba Paolo Dughiero Fabrizio Forzan Michele Mognaschi Maria Evelina Sgarbossa Paolo Sieni Elisabetta |
| author_sort | Bernardis Alessia |
| collection | DOAJ |
| description | In clinical treatments of a class of tumors, e.g. skin tumors, the drug uptake of tumor tissue is helped by means of a pulsed electric field, which permeabilizes the cell membranes. This technique, which is called electroporation, exploits the conductivity of the tissues: however, the tumor tissue could be characterized by inhomogeneous areas, eventually causing a non-uniform distribution of current. In this paper, the authors propose a field model to predict the effect of tissue inhomogeneity, which can affect the current density distribution. In particular, finite-element simulations, considering non-linear conductivity against field relationship, are developed. Measurements on a set of samples subject to controlled inhomogeneity make it possible to assess the numerical model in view of identifying the equivalent resistance between pairs of electrodes. |
| first_indexed | 2024-12-17T20:03:27Z |
| format | Article |
| id | doaj.art-b88d1d23d6b14cc1abed5d16468e110b |
| institution | Directory Open Access Journal |
| issn | 2391-5471 |
| language | English |
| last_indexed | 2024-12-17T20:03:27Z |
| publishDate | 2017-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Physics |
| spelling | doaj.art-b88d1d23d6b14cc1abed5d16468e110b2022-12-21T21:34:24ZengDe GruyterOpen Physics2391-54712017-12-0115179079610.1515/phys-2017-0092phys-2017-0092Electric field computation and measurements in the electroporation of inhomogeneous samplesBernardis Alessia0Bullo Marco1Campana Luca Giovanni2Di Barba Paolo3Dughiero Fabrizio4Forzan Michele5Mognaschi Maria Evelina6Sgarbossa Paolo7Sieni Elisabetta8Department of Industrial Engineering, University of PadovaVia Gradenigo, 6/a 35131, Padova, ItalyDepartment of Industrial Engineering, University of PadovaVia Gradenigo, 6/a 35131, Padova, ItalyVeneto Institute of Oncology IOV-IRCCS, Padova Italy, DISCOG University of PadovaVia Gattamelata, 35128, Padova, ItalyDepartment of Electrical, Computer and Biomedical Engineering, University of PaviaVia Ferrata, 5 27100, Pavia, ItalyDepartment of Industrial Engineering, University of PadovaVia Gradenigo, 6/a 35131, Padova, ItalyDepartment of Industrial Engineering, University of PadovaVia Gradenigo, 6/a 35131, Padova, ItalyDepartment of Electrical, Computer and Biomedical Engineering, University of PaviaVia Ferrata, 5 27100, Pavia, ItalyDepartment of Industrial Engineering, University of PadovaVia Gradenigo, 6/a 35131, Padova, ItalyDepartment of Industrial Engineering, University of PadovaVia Gradenigo, 6/a 35131, Padova, ItalyIn clinical treatments of a class of tumors, e.g. skin tumors, the drug uptake of tumor tissue is helped by means of a pulsed electric field, which permeabilizes the cell membranes. This technique, which is called electroporation, exploits the conductivity of the tissues: however, the tumor tissue could be characterized by inhomogeneous areas, eventually causing a non-uniform distribution of current. In this paper, the authors propose a field model to predict the effect of tissue inhomogeneity, which can affect the current density distribution. In particular, finite-element simulations, considering non-linear conductivity against field relationship, are developed. Measurements on a set of samples subject to controlled inhomogeneity make it possible to assess the numerical model in view of identifying the equivalent resistance between pairs of electrodes.https://doi.org/10.1515/phys-2017-0092clinical electroporationelectric field modelequivalent circuitresistivity identificationpotato samples87.50.c07.05.tp |
| spellingShingle | Bernardis Alessia Bullo Marco Campana Luca Giovanni Di Barba Paolo Dughiero Fabrizio Forzan Michele Mognaschi Maria Evelina Sgarbossa Paolo Sieni Elisabetta Electric field computation and measurements in the electroporation of inhomogeneous samples Open Physics clinical electroporation electric field model equivalent circuit resistivity identification potato samples 87.50.c 07.05.tp |
| title | Electric field computation and measurements in the electroporation of inhomogeneous samples |
| title_full | Electric field computation and measurements in the electroporation of inhomogeneous samples |
| title_fullStr | Electric field computation and measurements in the electroporation of inhomogeneous samples |
| title_full_unstemmed | Electric field computation and measurements in the electroporation of inhomogeneous samples |
| title_short | Electric field computation and measurements in the electroporation of inhomogeneous samples |
| title_sort | electric field computation and measurements in the electroporation of inhomogeneous samples |
| topic | clinical electroporation electric field model equivalent circuit resistivity identification potato samples 87.50.c 07.05.tp |
| url | https://doi.org/10.1515/phys-2017-0092 |
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