Current research on circular RNAs and their potential clinical implications in breast cancer
Breast cancer (BC) is one of the most common cancers and the leading causes of death among women worldwide, and its morbidity rate is growing. Discovery of novel biomarkers is necessary for early BC detection, treatment, and prognostication. Circular RNAs (circRNAs), a novel type of endogenous non-c...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2021-08-01
|
| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1856 |
| _version_ | 1818607768281546752 |
|---|---|
| author | Diya Liu Lin Fang |
| author_facet | Diya Liu Lin Fang |
| author_sort | Diya Liu |
| collection | DOAJ |
| description | Breast cancer (BC) is one of the most common cancers and the leading causes of death among women worldwide, and its morbidity rate is growing. Discovery of novel biomarkers is necessary for early BC detection, treatment, and prognostication. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs with covalently closed continuous loops, have been found to have a crucial role in tumorigenesis. Studies have demonstrated that circRNAs are aberrantly expressed in the tumor tissues and plasma of patients with BC, and they modulate gene expression affecting the proliferation, metastasis, and chemoresistance of BC by specifically binding and regulating the expression of microRNAs (miRNAs). Therefore, circRNAs can be used as novel potential diagnostic and prognostic markers, and therapeutic targets for BC. This article summarizes the properties, functions, and regulatory mechanisms of circRNAs, particularly current research on their association with BC proliferation, metastasis, and chemoresistance. |
| first_indexed | 2024-12-16T14:32:00Z |
| format | Article |
| id | doaj.art-b88f5b74327e4bacb65f0cf9f7d808a6 |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-12-16T14:32:00Z |
| publishDate | 2021-08-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-b88f5b74327e4bacb65f0cf9f7d808a62022-12-21T22:28:12ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412021-08-0118363564810.20892/j.issn.2095-3941.2020.0275Current research on circular RNAs and their potential clinical implications in breast cancerDiya Liu0Lin Fang1Department of Thyroid and Breast Diseases, Shanghai Tenth People’s Hospital, Shanghai 200070, ChinaDepartment of Thyroid and Breast Diseases, Shanghai Tenth People’s Hospital, Shanghai 200070, ChinaBreast cancer (BC) is one of the most common cancers and the leading causes of death among women worldwide, and its morbidity rate is growing. Discovery of novel biomarkers is necessary for early BC detection, treatment, and prognostication. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs with covalently closed continuous loops, have been found to have a crucial role in tumorigenesis. Studies have demonstrated that circRNAs are aberrantly expressed in the tumor tissues and plasma of patients with BC, and they modulate gene expression affecting the proliferation, metastasis, and chemoresistance of BC by specifically binding and regulating the expression of microRNAs (miRNAs). Therefore, circRNAs can be used as novel potential diagnostic and prognostic markers, and therapeutic targets for BC. This article summarizes the properties, functions, and regulatory mechanisms of circRNAs, particularly current research on their association with BC proliferation, metastasis, and chemoresistance.http://www.cancerbiomed.org/index.php/cocr/article/view/1856circular rnabreast cancerbiomarker |
| spellingShingle | Diya Liu Lin Fang Current research on circular RNAs and their potential clinical implications in breast cancer Cancer Biology & Medicine circular rna breast cancer biomarker |
| title | Current research on circular RNAs and their potential clinical implications in breast cancer |
| title_full | Current research on circular RNAs and their potential clinical implications in breast cancer |
| title_fullStr | Current research on circular RNAs and their potential clinical implications in breast cancer |
| title_full_unstemmed | Current research on circular RNAs and their potential clinical implications in breast cancer |
| title_short | Current research on circular RNAs and their potential clinical implications in breast cancer |
| title_sort | current research on circular rnas and their potential clinical implications in breast cancer |
| topic | circular rna breast cancer biomarker |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/1856 |
| work_keys_str_mv | AT diyaliu currentresearchoncircularrnasandtheirpotentialclinicalimplicationsinbreastcancer AT linfang currentresearchoncircularrnasandtheirpotentialclinicalimplicationsinbreastcancer |