DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis

DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis

Abstract Background MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates within chromatin structure, MMP-9 enzymatic activity toward H3NT is tightl...

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Bibliographic Details
Main Authors: Yonghwan Shin, Nikhil B. Ghate, Byoungsan Moon, Kyungpyo Park, Wange Lu, Woojin An
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Epigenetics & Chromatin
Subjects:
MMP-9
H3 proteolysis
DNA methylation
Osteoclast differentiation
5-Aza-dC
TSA
Online Access:http://link.springer.com/article/10.1186/s13072-019-0270-0

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