An AP endonuclease 1-DNA polymerase beta complex: theoretical prediction of interacting surfaces.

An AP endonuclease 1-DNA polymerase beta complex: theoretical prediction of interacting surfaces.

Abasic (AP) sites in DNA arise through both endogenous and exogenous mechanisms. Since AP sites can prevent replication and transcription, the cell contains systems for their identification and repair. AP endonuclease (APEX1) cleaves the phosphodiester backbone 5' to the AP site. The cleavage,...

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Bibliographic Details
Main Authors: Alexej Abyzov, Alper Uzun, Phyllis R Strauss, Valentin A Ilyin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2289873?pdf=render

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