Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis

Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis

Abstract Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to develop a novel class of antimicrobial therapy, based on human-derived hybrid host defense peptides (HyHDPs), for treating BK. HyHDPs were rationally designed through combination of functional amino...

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Bibliographic Details
Main Authors: Darren Shu Jeng Ting, Eunice Tze Leng Goh, Venkatesh Mayandi, Joanna M. F. Busoy, Thet Tun Aung, Mercy Halleluyah Periayah, Mario Nubile, Leonardo Mastropasqua, Dalia G. Said, Hla M. Htoon, Veluchamy Amutha Barathi, Roger W. Beuerman, Rajamani Lakshminarayanan, Imran Mohammed, Harminder S. Dua
Format: Article
Language:English
Published: Nature Portfolio 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97821-3

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