Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population
<p>Abstract</p> <p>Background</p> <p>Simpson-Angus Scale (SAS) is an established instrument for neuroleptic-induced parkinsonism (NIP), but its statistical properties have been studied insufficiently. Some shortcomings concerning its content have been suggested as well....
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| Format: | Article |
| Language: | English |
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BMC
2005-03-01
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| Series: | BMC Neurology |
| Online Access: | http://www.biomedcentral.com/1471-2377/5/5 |
| _version_ | 1811312262556680192 |
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| author | Tuisku Katinka Holi Matti M Janno Sven Wahlbeck Kristian |
| author_facet | Tuisku Katinka Holi Matti M Janno Sven Wahlbeck Kristian |
| author_sort | Tuisku Katinka |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Simpson-Angus Scale (SAS) is an established instrument for neuroleptic-induced parkinsonism (NIP), but its statistical properties have been studied insufficiently. Some shortcomings concerning its content have been suggested as well. According to a recent report, the widely used SAS mean score cut-off value 0.3 of for NIP detection may be too low. Our aim was to evaluate SAS against DSM-IV diagnostic criteria for NIP and objective motor assessment (actometry).</p> <p>Methods</p> <p>Ninety-nine chronic institutionalised schizophrenia patients were evaluated during the same interview by standardised actometric recording and SAS. The diagnosis of NIP was based on DSM-IV criteria. Internal consistency measured by Cronbach's α, convergence to actometry and the capacity for NIP case detection were assessed.</p> <p>Results</p> <p>Cronbach's α for the scale was 0.79. SAS discriminated between DSM-IV NIP and non-NIP patients. The actometric findings did not correlate with SAS. ROC-analysis yielded a good case detection power for SAS mean score. The optimal threshold value of SAS mean score was between 0.65 and 0.95, i.e. clearly higher than previously suggested threshold value.</p> <p>Conclusion</p> <p>We conclude that SAS seems a reliable and valid instrument. The previously commonly used cut-off mean score of 0.3 has been too low resulting in low specificity, and we suggest a new cut-off value of 0.65, whereby specificity could be doubled without loosing sensitivity.</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-13T10:33:01Z |
| publishDate | 2005-03-01 |
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| series | BMC Neurology |
| spelling | doaj.art-b896bcc33b954cedb8f18b09f33e65422022-12-22T02:50:07ZengBMCBMC Neurology1471-23772005-03-0151510.1186/1471-2377-5-5Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia populationTuisku KatinkaHoli Matti MJanno SvenWahlbeck Kristian<p>Abstract</p> <p>Background</p> <p>Simpson-Angus Scale (SAS) is an established instrument for neuroleptic-induced parkinsonism (NIP), but its statistical properties have been studied insufficiently. Some shortcomings concerning its content have been suggested as well. According to a recent report, the widely used SAS mean score cut-off value 0.3 of for NIP detection may be too low. Our aim was to evaluate SAS against DSM-IV diagnostic criteria for NIP and objective motor assessment (actometry).</p> <p>Methods</p> <p>Ninety-nine chronic institutionalised schizophrenia patients were evaluated during the same interview by standardised actometric recording and SAS. The diagnosis of NIP was based on DSM-IV criteria. Internal consistency measured by Cronbach's α, convergence to actometry and the capacity for NIP case detection were assessed.</p> <p>Results</p> <p>Cronbach's α for the scale was 0.79. SAS discriminated between DSM-IV NIP and non-NIP patients. The actometric findings did not correlate with SAS. ROC-analysis yielded a good case detection power for SAS mean score. The optimal threshold value of SAS mean score was between 0.65 and 0.95, i.e. clearly higher than previously suggested threshold value.</p> <p>Conclusion</p> <p>We conclude that SAS seems a reliable and valid instrument. The previously commonly used cut-off mean score of 0.3 has been too low resulting in low specificity, and we suggest a new cut-off value of 0.65, whereby specificity could be doubled without loosing sensitivity.</p>http://www.biomedcentral.com/1471-2377/5/5 |
| spellingShingle | Tuisku Katinka Holi Matti M Janno Sven Wahlbeck Kristian Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population BMC Neurology |
| title | Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population |
| title_full | Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population |
| title_fullStr | Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population |
| title_full_unstemmed | Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population |
| title_short | Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population |
| title_sort | validity of simpson angus scale sas in a naturalistic schizophrenia population |
| url | http://www.biomedcentral.com/1471-2377/5/5 |
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