Initiation and maintenance of acquired immunity in dry eye
Dry eye(DE)is a multifactorial ocular surface disorder arising from numerous pathologies. The pathogenesis of DE includes immune inflammation, oxidative stress, changes in tear film composition, corneal nerve abnormalities, and meibomian gland dysfunction. Among them, the immune inflammatory respons...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-04-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2024/4/202404007.pdf |
| _version_ | 1797249377444560896 |
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| author | Sun Wenxin Guo Yuli Liu Zuguo |
| author_facet | Sun Wenxin Guo Yuli Liu Zuguo |
| author_sort | Sun Wenxin |
| collection | DOAJ |
| description | Dry eye(DE)is a multifactorial ocular surface disorder arising from numerous pathologies. The pathogenesis of DE includes immune inflammation, oxidative stress, changes in tear film composition, corneal nerve abnormalities, and meibomian gland dysfunction. Among them, the immune inflammatory response is the most crucial in the pathogenesis of DE, which is regulated by both innate and acquired immune responses on the ocular surface. Multiple environmental stresses trigger the ocular surface innate immune response leading to corneal epithelial cell damage and inflammation and activate acquired immunity to participate in the ocular surface immune inflammatory response. Currently, multiple immune cells and inflammatory factors have been shown to be involved in the occurrence and development of DE. This article reviewed the immune progress and focused on the initiation and maintenance of acquired immunity in DE. Through the analysis of the latest viewpoints and research hot spots, we systematically introduced the immunomodulating mechanism underlying the mechanisms of the pathogenesis of DE and provided references for the prevention and treatment of DE. |
| first_indexed | 2024-04-24T20:29:31Z |
| format | Article |
| id | doaj.art-b899ab65e0834d54bfcfa49ad1c6102b |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-24T20:29:31Z |
| publishDate | 2024-04-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-b899ab65e0834d54bfcfa49ad1c6102b2024-03-22T03:14:27ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-04-0124453453810.3980/j.issn.1672-5123.2024.4.07202404007Initiation and maintenance of acquired immunity in dry eyeSun Wenxin0Guo Yuli1Liu Zuguo2Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China; Department of Ophthalmology, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, ChinaHengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China; Department of Ophthalmology, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, ChinaHengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China; Department of Ophthalmology, the First Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, China; Eye Institute of Xiamen University;Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen 361102, Fujian Province, ChinaDry eye(DE)is a multifactorial ocular surface disorder arising from numerous pathologies. The pathogenesis of DE includes immune inflammation, oxidative stress, changes in tear film composition, corneal nerve abnormalities, and meibomian gland dysfunction. Among them, the immune inflammatory response is the most crucial in the pathogenesis of DE, which is regulated by both innate and acquired immune responses on the ocular surface. Multiple environmental stresses trigger the ocular surface innate immune response leading to corneal epithelial cell damage and inflammation and activate acquired immunity to participate in the ocular surface immune inflammatory response. Currently, multiple immune cells and inflammatory factors have been shown to be involved in the occurrence and development of DE. This article reviewed the immune progress and focused on the initiation and maintenance of acquired immunity in DE. Through the analysis of the latest viewpoints and research hot spots, we systematically introduced the immunomodulating mechanism underlying the mechanisms of the pathogenesis of DE and provided references for the prevention and treatment of DE.http://ies.ijo.cn/cn_publish/2024/4/202404007.pdfdry eyeinnate immunityacquired immunitypathogenesis |
| spellingShingle | Sun Wenxin Guo Yuli Liu Zuguo Initiation and maintenance of acquired immunity in dry eye Guoji Yanke Zazhi dry eye innate immunity acquired immunity pathogenesis |
| title | Initiation and maintenance of acquired immunity in dry eye |
| title_full | Initiation and maintenance of acquired immunity in dry eye |
| title_fullStr | Initiation and maintenance of acquired immunity in dry eye |
| title_full_unstemmed | Initiation and maintenance of acquired immunity in dry eye |
| title_short | Initiation and maintenance of acquired immunity in dry eye |
| title_sort | initiation and maintenance of acquired immunity in dry eye |
| topic | dry eye innate immunity acquired immunity pathogenesis |
| url | http://ies.ijo.cn/cn_publish/2024/4/202404007.pdf |
| work_keys_str_mv | AT sunwenxin initiationandmaintenanceofacquiredimmunityindryeye AT guoyuli initiationandmaintenanceofacquiredimmunityindryeye AT liuzuguo initiationandmaintenanceofacquiredimmunityindryeye |