Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis
Abstract Mast cells are phenotypically and functionally heterogeneous, and their state is possibly controlled by local microenvironment. Therefore, specific analyses are needed to understand whether mast cells function as powerful participants or dispensable bystanders in specific diseases. Here, we...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-44304-w |
| _version_ | 1797363114799267840 |
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| author | Yunxuan Lei Xin Guo Yanping Luo Xiaoyin Niu Yebin Xi Lianbo Xiao Dongyi He Yanqin Bian Yong Zhang Li Wang Xiaochun Peng Zhaojun Wang Guangjie Chen |
| author_facet | Yunxuan Lei Xin Guo Yanping Luo Xiaoyin Niu Yebin Xi Lianbo Xiao Dongyi He Yanqin Bian Yong Zhang Li Wang Xiaochun Peng Zhaojun Wang Guangjie Chen |
| author_sort | Yunxuan Lei |
| collection | DOAJ |
| description | Abstract Mast cells are phenotypically and functionally heterogeneous, and their state is possibly controlled by local microenvironment. Therefore, specific analyses are needed to understand whether mast cells function as powerful participants or dispensable bystanders in specific diseases. Here, we show that degranulation of mast cells in inflammatory synovial tissues of patients with rheumatoid arthritis (RA) is induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), and the expression of MHC class II and costimulatory molecules on mast cells are upregulated. Collagen-induced arthritis mice treated with a combination of anti-IL-17A and cromolyn sodium, a mast cell membrane stabilizer, show significantly reduced clinical severity and decreased bone erosion. The findings of the present study suggest that synovial microenvironment-influenced mast cells contribute to disease progression and may provide a further mast cell-targeting therapy for RA. |
| first_indexed | 2024-03-08T16:16:39Z |
| format | Article |
| id | doaj.art-b89a808948604c699c9335dc5ecee114 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-08T16:16:39Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b89a808948604c699c9335dc5ecee1142024-01-07T12:35:30ZengNature PortfolioNature Communications2041-17232024-01-0115111410.1038/s41467-023-44304-wSynovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritisYunxuan Lei0Xin Guo1Yanping Luo2Xiaoyin Niu3Yebin Xi4Lianbo Xiao5Dongyi He6Yanqin Bian7Yong Zhang8Li Wang9Xiaochun Peng10Zhaojun Wang11Guangjie Chen12Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Joint Surgery, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese MedicineInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese MedicineDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Orthopedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyDepartment of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of ImmunologyAbstract Mast cells are phenotypically and functionally heterogeneous, and their state is possibly controlled by local microenvironment. Therefore, specific analyses are needed to understand whether mast cells function as powerful participants or dispensable bystanders in specific diseases. Here, we show that degranulation of mast cells in inflammatory synovial tissues of patients with rheumatoid arthritis (RA) is induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), and the expression of MHC class II and costimulatory molecules on mast cells are upregulated. Collagen-induced arthritis mice treated with a combination of anti-IL-17A and cromolyn sodium, a mast cell membrane stabilizer, show significantly reduced clinical severity and decreased bone erosion. The findings of the present study suggest that synovial microenvironment-influenced mast cells contribute to disease progression and may provide a further mast cell-targeting therapy for RA.https://doi.org/10.1038/s41467-023-44304-w |
| spellingShingle | Yunxuan Lei Xin Guo Yanping Luo Xiaoyin Niu Yebin Xi Lianbo Xiao Dongyi He Yanqin Bian Yong Zhang Li Wang Xiaochun Peng Zhaojun Wang Guangjie Chen Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis Nature Communications |
| title | Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis |
| title_full | Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis |
| title_fullStr | Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis |
| title_full_unstemmed | Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis |
| title_short | Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis |
| title_sort | synovial microenvironment influenced mast cells promote the progression of rheumatoid arthritis |
| url | https://doi.org/10.1038/s41467-023-44304-w |
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