Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases
Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. However, <i>SDH</i> mutation or dysfunction-induced succinate accumulation results in multiple cancers and non-cancer diseases. The mechanist...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/11/3237 |
| _version_ | 1797548972767707136 |
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| author | Cerena Moreno Ruben Mercado Santos Robert Burns Wen Cai Zhang |
| author_facet | Cerena Moreno Ruben Mercado Santos Robert Burns Wen Cai Zhang |
| author_sort | Cerena Moreno |
| collection | DOAJ |
| description | Succinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. However, <i>SDH</i> mutation or dysfunction-induced succinate accumulation results in multiple cancers and non-cancer diseases. The mechanistic studies show that succinate activates hypoxia response and other signal pathways via binding to 2-oxoglutarate-dependent oxygenases and succinate receptors. Recently, the increasing knowledge of ribonucleic acid (RNA) networks, including non-coding RNAs, RNA editors, and RNA modifiers has expanded our understanding of the interplay between SDH and RNA networks in cancer and other diseases. Here, we summarize recent discoveries in the RNA networks and their connections to SDH. Additionally, we discuss current therapeutics targeting SDH in both pre-clinical and clinical trials. Thus, we propose a new model of SDH–RNA network interaction and bring promising RNA therapeutics against SDH-relevant cancer and other diseases. |
| first_indexed | 2024-03-10T15:08:22Z |
| format | Article |
| id | doaj.art-b89b019477c248c1994de0903235d3d8 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:08:22Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b89b019477c248c1994de0903235d3d82023-11-20T19:36:22ZengMDPI AGCancers2072-66942020-11-011211323710.3390/cancers12113237Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other DiseasesCerena Moreno0Ruben Mercado Santos1Robert Burns2Wen Cai Zhang3Department of Cancer Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd, Orlando, FL 32827, USADepartment of Cancer Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd, Orlando, FL 32827, USADepartment of Cancer Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd, Orlando, FL 32827, USADepartment of Cancer Division, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Blvd, Orlando, FL 32827, USASuccinate dehydrogenase (SDH) complex connects both the tricarboxylic acid (TCA) cycle and the electron transport chain (ETC) in the mitochondria. However, <i>SDH</i> mutation or dysfunction-induced succinate accumulation results in multiple cancers and non-cancer diseases. The mechanistic studies show that succinate activates hypoxia response and other signal pathways via binding to 2-oxoglutarate-dependent oxygenases and succinate receptors. Recently, the increasing knowledge of ribonucleic acid (RNA) networks, including non-coding RNAs, RNA editors, and RNA modifiers has expanded our understanding of the interplay between SDH and RNA networks in cancer and other diseases. Here, we summarize recent discoveries in the RNA networks and their connections to SDH. Additionally, we discuss current therapeutics targeting SDH in both pre-clinical and clinical trials. Thus, we propose a new model of SDH–RNA network interaction and bring promising RNA therapeutics against SDH-relevant cancer and other diseases.https://www.mdpi.com/2072-6694/12/11/3237succinate dehydrogenasecancerdiseasetricarboxylic acid cycleelectron transport chainmetabolism |
| spellingShingle | Cerena Moreno Ruben Mercado Santos Robert Burns Wen Cai Zhang Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases Cancers succinate dehydrogenase cancer disease tricarboxylic acid cycle electron transport chain metabolism |
| title | Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases |
| title_full | Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases |
| title_fullStr | Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases |
| title_full_unstemmed | Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases |
| title_short | Succinate Dehydrogenase and Ribonucleic Acid Networks in Cancer and Other Diseases |
| title_sort | succinate dehydrogenase and ribonucleic acid networks in cancer and other diseases |
| topic | succinate dehydrogenase cancer disease tricarboxylic acid cycle electron transport chain metabolism |
| url | https://www.mdpi.com/2072-6694/12/11/3237 |
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