Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)
Abstract Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challengi...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
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| Series: | Chinese Neurosurgical Journal |
| Online Access: | https://doi.org/10.1186/s41016-024-00358-3 |
| _version_ | 1827328629181251584 |
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| author | Peicong Ge Zihan Yin Chuming Tao Chaofan Zeng Xiaofan Yu Shixiong Lei Junsheng Li Yuanren Zhai Long Ma Qiheng He Chenglong Liu Wei Liu Bojian Zhang Zhiyao Zheng Siqi Mou Zhikang Zhao Shuang Wang Wei Sun Min Guo Shuai Zheng Jia Zhang Xiaofeng Deng Xingju Liu Xun Ye Qian Zhang Rong Wang Yan Zhang Shaosen Zhang Chengjun Wang Ziwen Yang Nijia Zhang Mingxing Wu Jian Sun Yujia Zhou Zhiyong Shi Yonggang Ma Jianpo Zhou Shaochen Yu Jiaxi Li Junli Lu Faliang Gao Wenjing Wang Yanming Chen Xingen Zhu Dong Zhang Jizong Zhao |
| author_facet | Peicong Ge Zihan Yin Chuming Tao Chaofan Zeng Xiaofan Yu Shixiong Lei Junsheng Li Yuanren Zhai Long Ma Qiheng He Chenglong Liu Wei Liu Bojian Zhang Zhiyao Zheng Siqi Mou Zhikang Zhao Shuang Wang Wei Sun Min Guo Shuai Zheng Jia Zhang Xiaofeng Deng Xingju Liu Xun Ye Qian Zhang Rong Wang Yan Zhang Shaosen Zhang Chengjun Wang Ziwen Yang Nijia Zhang Mingxing Wu Jian Sun Yujia Zhou Zhiyong Shi Yonggang Ma Jianpo Zhou Shaochen Yu Jiaxi Li Junli Lu Faliang Gao Wenjing Wang Yanming Chen Xingen Zhu Dong Zhang Jizong Zhao |
| author_sort | Peicong Ge |
| collection | DOAJ |
| description | Abstract Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic strategies. Methods The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD patients. Conclusions The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease. |
| first_indexed | 2024-03-07T15:20:16Z |
| format | Article |
| id | doaj.art-b89e7299a03f4992888ba38e5512f4a9 |
| institution | Directory Open Access Journal |
| issn | 2057-4967 |
| language | English |
| last_indexed | 2024-03-07T15:20:16Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Neurosurgical Journal |
| spelling | doaj.art-b89e7299a03f4992888ba38e5512f4a92024-03-05T17:43:25ZengBMCChinese Neurosurgical Journal2057-49672024-02-011011910.1186/s41016-024-00358-3Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)Peicong Ge0Zihan Yin1Chuming Tao2Chaofan Zeng3Xiaofan Yu4Shixiong Lei5Junsheng Li6Yuanren Zhai7Long Ma8Qiheng He9Chenglong Liu10Wei Liu11Bojian Zhang12Zhiyao Zheng13Siqi Mou14Zhikang Zhao15Shuang Wang16Wei Sun17Min Guo18Shuai Zheng19Jia Zhang20Xiaofeng Deng21Xingju Liu22Xun Ye23Qian Zhang24Rong Wang25Yan Zhang26Shaosen Zhang27Chengjun Wang28Ziwen Yang29Nijia Zhang30Mingxing Wu31Jian Sun32Yujia Zhou33Zhiyong Shi34Yonggang Ma35Jianpo Zhou36Shaochen Yu37Jiaxi Li38Junli Lu39Faliang Gao40Wenjing Wang41Yanming Chen42Xingen Zhu43Dong Zhang44Jizong Zhao45Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Hospital, National Center of GerontologyDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Radiology, Beijing Tiantan HospitalDepartment of Ultrasound, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Tiantan HospitalDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Hospital, National Center of GerontologyDepartment of Neurosurgery, Beijing Friendship Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Childrens Hospital, Capital Medical UniversityDepartment of Neurosurgery, The Affiliated Children’s Hospital, Capital Institute of PediatricsDepartment of Neurosurgery, Beijing Changping District HospitalDepartment of Neurosurgery, Dongfang Hospital, Beijing University of Chinese MedicineDepartment of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical SchoolDepartment of NeuroInterventional Surgery, Binzhou Medical University HospitalDepartment of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurosurgery, West China Hospital, Sichuan UniversityDepartment of Neurosurgery, Center for Rehabilitation Medicine, Zhejiang Provincial Peoples Hospital, Affiliated Peoples Hospital, Hangzhou Medical CollegeBeijing Institute of Hepatology, Beijing YouAn Hospital, Capital Medical UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Soochow UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Nanchang UniversityDepartment of Neurosurgery, Beijing Hospital, National Center of GerontologyDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic strategies. Methods The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD patients. Conclusions The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.https://doi.org/10.1186/s41016-024-00358-3 |
| spellingShingle | Peicong Ge Zihan Yin Chuming Tao Chaofan Zeng Xiaofan Yu Shixiong Lei Junsheng Li Yuanren Zhai Long Ma Qiheng He Chenglong Liu Wei Liu Bojian Zhang Zhiyao Zheng Siqi Mou Zhikang Zhao Shuang Wang Wei Sun Min Guo Shuai Zheng Jia Zhang Xiaofeng Deng Xingju Liu Xun Ye Qian Zhang Rong Wang Yan Zhang Shaosen Zhang Chengjun Wang Ziwen Yang Nijia Zhang Mingxing Wu Jian Sun Yujia Zhou Zhiyong Shi Yonggang Ma Jianpo Zhou Shaochen Yu Jiaxi Li Junli Lu Faliang Gao Wenjing Wang Yanming Chen Xingen Zhu Dong Zhang Jizong Zhao Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS) Chinese Neurosurgical Journal |
| title | Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS) |
| title_full | Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS) |
| title_fullStr | Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS) |
| title_full_unstemmed | Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS) |
| title_short | Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS) |
| title_sort | multiomics and blood based biomarkers of moyamoya disease protocol of moyamoya omics atlas moyaomics |
| url | https://doi.org/10.1186/s41016-024-00358-3 |
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