Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection
Resident memory T cells at the respiratory tract may play critical roles in the response to respiratory infections including SARS-CoV-2. Here the authors characterise the lung resident T cell response generated in response to mRNA vaccination of SARS-CoV-2 Spike or in convalescent patients after nat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37559-w |
| _version_ | 1797849988393336832 |
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| author | Daan K. J. Pieren Sebastián G. Kuguel Joel Rosado Alba G. Robles Joan Rey-Cano Cristina Mancebo Juliana Esperalba Vicenç Falcó María J. Buzón Meritxell Genescà |
| author_facet | Daan K. J. Pieren Sebastián G. Kuguel Joel Rosado Alba G. Robles Joan Rey-Cano Cristina Mancebo Juliana Esperalba Vicenç Falcó María J. Buzón Meritxell Genescà |
| author_sort | Daan K. J. Pieren |
| collection | DOAJ |
| description | Resident memory T cells at the respiratory tract may play critical roles in the response to respiratory infections including SARS-CoV-2. Here the authors characterise the lung resident T cell response generated in response to mRNA vaccination of SARS-CoV-2 Spike or in convalescent patients after natural infection. They show reduced frequency and functionality of tissue resident T cells in vaccinated versus convalescent patients which may impact disease control and vaccination strategies. |
| first_indexed | 2024-04-09T18:53:04Z |
| format | Article |
| id | doaj.art-b8a0e4089b56401485e27f8edd61d902 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:53:04Z |
| publishDate | 2023-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b8a0e4089b56401485e27f8edd61d9022023-04-09T11:21:43ZengNature PortfolioNature Communications2041-17232023-04-0114111410.1038/s41467-023-37559-wLimited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infectionDaan K. J. Pieren0Sebastián G. Kuguel1Joel Rosado2Alba G. Robles3Joan Rey-Cano4Cristina Mancebo5Juliana Esperalba6Vicenç Falcó7María J. Buzón8Meritxell Genescà9Infectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusThoracic Surgery and Lung Transplantation Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusRespiratory Viruses Unit, Microbiology Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusInfectious Diseases Department, Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Hospital Universitari, Vall d’Hebron Barcelona Hospital CampusResident memory T cells at the respiratory tract may play critical roles in the response to respiratory infections including SARS-CoV-2. Here the authors characterise the lung resident T cell response generated in response to mRNA vaccination of SARS-CoV-2 Spike or in convalescent patients after natural infection. They show reduced frequency and functionality of tissue resident T cells in vaccinated versus convalescent patients which may impact disease control and vaccination strategies.https://doi.org/10.1038/s41467-023-37559-w |
| spellingShingle | Daan K. J. Pieren Sebastián G. Kuguel Joel Rosado Alba G. Robles Joan Rey-Cano Cristina Mancebo Juliana Esperalba Vicenç Falcó María J. Buzón Meritxell Genescà Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection Nature Communications |
| title | Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection |
| title_full | Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection |
| title_fullStr | Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection |
| title_full_unstemmed | Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection |
| title_short | Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection |
| title_sort | limited induction of polyfunctional lung resident memory t cells against sars cov 2 by mrna vaccination compared to infection |
| url | https://doi.org/10.1038/s41467-023-37559-w |
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