Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells
Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage to the heart, kidney, eyes, and nerves. Elevated blood glucose levels damage brain function and cognitive abilities. They also lead to various neurological and neuropsychiatric disord...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-03-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/14/3/284 |
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| author | Vishal Chavda Dhananjay Yadav Snehal Patel Minseok Song |
| author_facet | Vishal Chavda Dhananjay Yadav Snehal Patel Minseok Song |
| author_sort | Vishal Chavda |
| collection | DOAJ |
| description | Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage to the heart, kidney, eyes, and nerves. Elevated blood glucose levels damage brain function and cognitive abilities. They also lead to various neurological and neuropsychiatric disorders, including chronic neurodegeneration and cognitive decline. High neuronal glucose levels can cause drastic neuronal damage due to glucose neurotoxicity. Astrocytes, a type of glial cell, play a vital role in maintaining brain glucose levels through neuron–astrocyte coupling. Hyperglycemia leads to progressive decline in neuronal networks and cognitive impairment, contributing to neuronal dysfunction and fostering a neurodegenerative environment. In this review, we summarize the various connections, functions, and impairments of glial cells due to metabolic dysfunction in the diabetic brain. We also summarize the effects of hyperglycemia on various neuronal functions in the diabetic brain. |
| first_indexed | 2024-04-24T18:29:23Z |
| format | Article |
| id | doaj.art-b8a4c7c36d5840c8a821dd1725df6ee5 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-24T18:29:23Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-b8a4c7c36d5840c8a821dd1725df6ee52024-03-27T13:28:51ZengMDPI AGBrain Sciences2076-34252024-03-0114328410.3390/brainsci14030284Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological CellsVishal Chavda0Dhananjay Yadav1Snehal Patel2Minseok Song3Pharmacology Research Lab, Department of Pharmacology, Nirma University, Ahmedabad 382481, IndiaDepartment of Life Science, Yeungnam University, Gyeongsan 38541, Republic of KoreaPharmacology Research Lab, Department of Pharmacology, Nirma University, Ahmedabad 382481, IndiaDepartment of Life Science, Yeungnam University, Gyeongsan 38541, Republic of KoreaDiabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage to the heart, kidney, eyes, and nerves. Elevated blood glucose levels damage brain function and cognitive abilities. They also lead to various neurological and neuropsychiatric disorders, including chronic neurodegeneration and cognitive decline. High neuronal glucose levels can cause drastic neuronal damage due to glucose neurotoxicity. Astrocytes, a type of glial cell, play a vital role in maintaining brain glucose levels through neuron–astrocyte coupling. Hyperglycemia leads to progressive decline in neuronal networks and cognitive impairment, contributing to neuronal dysfunction and fostering a neurodegenerative environment. In this review, we summarize the various connections, functions, and impairments of glial cells due to metabolic dysfunction in the diabetic brain. We also summarize the effects of hyperglycemia on various neuronal functions in the diabetic brain.https://www.mdpi.com/2076-3425/14/3/284astrocytesdiabetesmetabolic complicationsglial dysfunctionneurodegeneration |
| spellingShingle | Vishal Chavda Dhananjay Yadav Snehal Patel Minseok Song Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells Brain Sciences astrocytes diabetes metabolic complications glial dysfunction neurodegeneration |
| title | Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells |
| title_full | Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells |
| title_fullStr | Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells |
| title_full_unstemmed | Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells |
| title_short | Effects of a Diabetic Microenvironment on Neurodegeneration: Special Focus on Neurological Cells |
| title_sort | effects of a diabetic microenvironment on neurodegeneration special focus on neurological cells |
| topic | astrocytes diabetes metabolic complications glial dysfunction neurodegeneration |
| url | https://www.mdpi.com/2076-3425/14/3/284 |
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