Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma
Stereotactic radiosurgery (SRS) is known to provide excellent tumor control with functional preservation for vestibular schwannomas (VS), but its efficacy in the other major intracranial schwannomas including trigeminal (TS), facial (FS), and jugular foramen schwannomas (JFS) has not been establishe...
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/5/1140 |
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| author | Yuki Shinya Hirotaka Hasegawa Masahiro Shin Takehiro Sugiyama Mariko Kawashima Atsuto Katano Akinori Kashio Kenji Kondo Nobuhito Saito |
| author_facet | Yuki Shinya Hirotaka Hasegawa Masahiro Shin Takehiro Sugiyama Mariko Kawashima Atsuto Katano Akinori Kashio Kenji Kondo Nobuhito Saito |
| author_sort | Yuki Shinya |
| collection | DOAJ |
| description | Stereotactic radiosurgery (SRS) is known to provide excellent tumor control with functional preservation for vestibular schwannomas (VS), but its efficacy in the other major intracranial schwannomas including trigeminal (TS), facial (FS), and jugular foramen schwannomas (JFS) has not been established yet due to their rarity. We retrospectively analyzed data of 514 consecutive patients who had intracranial schwannomas (460 VS, 22 TS, 7 FS, and 25 JFS) and underwent SRS. The 5- and 10-year tumor control rates were 97% and 94% for VS, 100% and 100% for TS, 80% and 80% for FS, and 100% and 80% for JFS. Radiation-induced complications included one hydrocephalus for TS (4.5%), no cases for FS (0%), and one hydrocephalus and one lower palsy for JFS (8.0%). Through matched cohort analysis between patients with VS and each of the non-VS, we found no statistical difference in tumor control and radiation-induced adverse events. SRS seems to provide long-term tumor control with functional preservation for TS, FS and JFS and the efficacies are similar to VS. |
| first_indexed | 2024-03-09T05:08:22Z |
| format | Article |
| id | doaj.art-b8a4d89492a945808eaf8685a17e58f0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T05:08:22Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b8a4d89492a945808eaf8685a17e58f02023-12-03T12:52:38ZengMDPI AGCancers2072-66942021-03-01135114010.3390/cancers13051140Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular SchwannomaYuki Shinya0Hirotaka Hasegawa1Masahiro Shin2Takehiro Sugiyama3Mariko Kawashima4Atsuto Katano5Akinori Kashio6Kenji Kondo7Nobuhito Saito8Department of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, JapanDiabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine, Tokyo 162-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Radiology, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Otorhinolaryngology, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Otorhinolaryngology, The University of Tokyo Hospital, Tokyo 113-8655, JapanDepartment of Neurosurgery, The University of Tokyo Hospital, Tokyo 113-8655, JapanStereotactic radiosurgery (SRS) is known to provide excellent tumor control with functional preservation for vestibular schwannomas (VS), but its efficacy in the other major intracranial schwannomas including trigeminal (TS), facial (FS), and jugular foramen schwannomas (JFS) has not been established yet due to their rarity. We retrospectively analyzed data of 514 consecutive patients who had intracranial schwannomas (460 VS, 22 TS, 7 FS, and 25 JFS) and underwent SRS. The 5- and 10-year tumor control rates were 97% and 94% for VS, 100% and 100% for TS, 80% and 80% for FS, and 100% and 80% for JFS. Radiation-induced complications included one hydrocephalus for TS (4.5%), no cases for FS (0%), and one hydrocephalus and one lower palsy for JFS (8.0%). Through matched cohort analysis between patients with VS and each of the non-VS, we found no statistical difference in tumor control and radiation-induced adverse events. SRS seems to provide long-term tumor control with functional preservation for TS, FS and JFS and the efficacies are similar to VS.https://www.mdpi.com/2072-6694/13/5/1140intracranial schwannomasstereotactic radiosurgerylong-term outcomesmatched cohort analyses |
| spellingShingle | Yuki Shinya Hirotaka Hasegawa Masahiro Shin Takehiro Sugiyama Mariko Kawashima Atsuto Katano Akinori Kashio Kenji Kondo Nobuhito Saito Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma Cancers intracranial schwannomas stereotactic radiosurgery long-term outcomes matched cohort analyses |
| title | Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma |
| title_full | Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma |
| title_fullStr | Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma |
| title_full_unstemmed | Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma |
| title_short | Long-Term Outcomes of Stereotactic Radiosurgery for Trigeminal, Facial, and Jugular Foramen Schwannoma in Comparison with Vestibular Schwannoma |
| title_sort | long term outcomes of stereotactic radiosurgery for trigeminal facial and jugular foramen schwannoma in comparison with vestibular schwannoma |
| topic | intracranial schwannomas stereotactic radiosurgery long-term outcomes matched cohort analyses |
| url | https://www.mdpi.com/2072-6694/13/5/1140 |
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