The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases
The aim of this study was to assess the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels in patients undergoing resection of pulmonary oligometastases. A retrospective analysis on 141 patients undergoing a first pulmonary metastasectomy in a s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/10/3378 |
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| author | Francesco Londero William Grossi Orlando Parise Jacqueline Cinel Gianmarco Parise Gianluca Masullo Cecilia Tetta Linda Renata Micali Emanuela Mauro Angelo Morelli Jos G. Maessen Sandro Gelsomino |
| author_facet | Francesco Londero William Grossi Orlando Parise Jacqueline Cinel Gianmarco Parise Gianluca Masullo Cecilia Tetta Linda Renata Micali Emanuela Mauro Angelo Morelli Jos G. Maessen Sandro Gelsomino |
| author_sort | Francesco Londero |
| collection | DOAJ |
| description | The aim of this study was to assess the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels in patients undergoing resection of pulmonary oligometastases. A retrospective analysis on 141 patients undergoing a first pulmonary metastasectomy in a single center was carried out. Two distinct analysis were performed subdividing patients according to their NLR ratio and CRP level. The main outcomes were survival and time to recurrence. At completion of follow-up 74 patients were still alive (52.5%). Subdividing patients according to their NLR yielded a significant difference in five-year progression-free survival (PFS, NLR < 4:32% vs. NLR ≥ 4:18%, <i>p</i> = 0.01). When subdivided by their CRP levels, patients with preoperative CRP < 5 mg/L demonstrated higher values of five-year overall survival (OS, 57% vs. 34%, <i>p</i> = 0.006) and five-year PFS (35% vs. 22%, <i>p</i> = 0.04). At multivariate analysis, level of neutrophils (<i>p</i> = 0.009) and lung comorbidities (<i>p</i> = 0.021) were independent predictors of death, whereas preoperative CRP (<i>p</i> = 0.002), multiple metastases (<i>p</i> = 0.003) and presence of lung comorbidities (<i>p</i> = 0.001) were independent predictors of recurrence. NLR and CRP are important predictors of prognostic outcome in patients undergoing pulmonary metastasectomy. |
| first_indexed | 2024-03-10T15:26:51Z |
| format | Article |
| id | doaj.art-b8a570841c1d44cebd0f966169cef830 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T15:26:51Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b8a570841c1d44cebd0f966169cef8302023-11-20T18:00:37ZengMDPI AGJournal of Clinical Medicine2077-03832020-10-01910337810.3390/jcm9103378The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary OligometastasesFrancesco Londero0William Grossi1Orlando Parise2Jacqueline Cinel3Gianmarco Parise4Gianluca Masullo5Cecilia Tetta6Linda Renata Micali7Emanuela Mauro8Angelo Morelli9Jos G. Maessen10Sandro Gelsomino11Cardiothoracic Department, Azienda Sanitaria Universitaria Integrata, 33100 Udine, ItalyCardiothoracic Department, Azienda Sanitaria Universitaria Integrata, 33100 Udine, ItalyCardiovascular Research Institute, Maastricht University, 6229 ER Maastricht, The NetherlandsCardiothoracic Department, Azienda Sanitaria Universitaria Integrata, 33100 Udine, ItalyCardiovascular Research Institute, Maastricht University, 6229 ER Maastricht, The NetherlandsCardiothoracic Department, Azienda Sanitaria Universitaria Integrata, 33100 Udine, ItalyRadiology Department, Rizzoli Institute, 40136 Bologna, ItalyCardiovascular Research Institute, Maastricht University, 6229 ER Maastricht, The NetherlandsCardiovascular Research Institute, Maastricht University, 6229 ER Maastricht, The NetherlandsCardiothoracic Department, Azienda Sanitaria Universitaria Integrata, 33100 Udine, ItalyCardiovascular Research Institute, Maastricht University, 6229 ER Maastricht, The NetherlandsCardiovascular Research Institute, Maastricht University, 6229 ER Maastricht, The NetherlandsThe aim of this study was to assess the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels in patients undergoing resection of pulmonary oligometastases. A retrospective analysis on 141 patients undergoing a first pulmonary metastasectomy in a single center was carried out. Two distinct analysis were performed subdividing patients according to their NLR ratio and CRP level. The main outcomes were survival and time to recurrence. At completion of follow-up 74 patients were still alive (52.5%). Subdividing patients according to their NLR yielded a significant difference in five-year progression-free survival (PFS, NLR < 4:32% vs. NLR ≥ 4:18%, <i>p</i> = 0.01). When subdivided by their CRP levels, patients with preoperative CRP < 5 mg/L demonstrated higher values of five-year overall survival (OS, 57% vs. 34%, <i>p</i> = 0.006) and five-year PFS (35% vs. 22%, <i>p</i> = 0.04). At multivariate analysis, level of neutrophils (<i>p</i> = 0.009) and lung comorbidities (<i>p</i> = 0.021) were independent predictors of death, whereas preoperative CRP (<i>p</i> = 0.002), multiple metastases (<i>p</i> = 0.003) and presence of lung comorbidities (<i>p</i> = 0.001) were independent predictors of recurrence. NLR and CRP are important predictors of prognostic outcome in patients undergoing pulmonary metastasectomy.https://www.mdpi.com/2077-0383/9/10/3378pulmonary oligometastasessurgeryneutrophilsC-reactive protein |
| spellingShingle | Francesco Londero William Grossi Orlando Parise Jacqueline Cinel Gianmarco Parise Gianluca Masullo Cecilia Tetta Linda Renata Micali Emanuela Mauro Angelo Morelli Jos G. Maessen Sandro Gelsomino The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases Journal of Clinical Medicine pulmonary oligometastases surgery neutrophils C-reactive protein |
| title | The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases |
| title_full | The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases |
| title_fullStr | The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases |
| title_full_unstemmed | The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases |
| title_short | The Impact of Preoperative Inflammatory Markers on the Prognosis of Patients Undergoing Surgical Resection of Pulmonary Oligometastases |
| title_sort | impact of preoperative inflammatory markers on the prognosis of patients undergoing surgical resection of pulmonary oligometastases |
| topic | pulmonary oligometastases surgery neutrophils C-reactive protein |
| url | https://www.mdpi.com/2077-0383/9/10/3378 |
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