Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

Role of glycogen synthase kinase 3 beta (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells

<p>Abstract</p> <p>Histone deacetylase inhibitors (HDACIs) have been shown to induce apoptotic and autophagic cell death <it>in vitro </it>and <it>in vivo</it>. The molecular mechanisms that underlie these cytotoxic effects are not yet clearly understood. Re...

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Bibliographic Details
Main Authors:	Lam Eric, Stavropoulou Alexandra V, Alao John P, Coombes R Charles
Format:	Article
Language:	English
Published:	BMC 2006-10-01
Series:	Molecular Cancer
Online Access:	http://www.molecular-cancer.com/content/5/1/40

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