Immune-related biomarkers for Parkinson's disease
Despite the increasing number of studies on Parkinson's disease and it being the second most common neurodegenerative disorder in the world, no established diagnostic markers or disease modifying therapies are available. Understanding the mechanisms involved in its pathogenesis and identifying...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996122001632 |
| _version_ | 1818546983926759424 |
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| author | Ilham Y. Abdi Simona S. Ghanem Omar M. El-Agnaf |
| author_facet | Ilham Y. Abdi Simona S. Ghanem Omar M. El-Agnaf |
| author_sort | Ilham Y. Abdi |
| collection | DOAJ |
| description | Despite the increasing number of studies on Parkinson's disease and it being the second most common neurodegenerative disorder in the world, no established diagnostic markers or disease modifying therapies are available. Understanding the mechanisms involved in its pathogenesis and identifying markers capable of diagnosing or tracking progression of PD is greatly needed. Among the several factors identified to be involved in Parkinson's disease, the immune system has had increasingly growing evidence that presents a fresh avenue to investigate the pathology of the disease. The involvement of the immune system in the pathology of Parkinson's disease has been linked to an interaction between the peripheral and central nervous system immune response. Whether this involvement is due to an immune response being a cause or consequence of Parkinson's disease pathology is still a matter of debate. Players investigated include cytokines, chemokines, and immune-cells found in both the central and peripheral immune system. Herein, we discuss advances in the current literature on these immune-related markers and their potential use as markers for Parkinson's disease diagnosis and progression. |
| first_indexed | 2024-12-12T08:00:32Z |
| format | Article |
| id | doaj.art-b8a8c9e0cc10421a860d41d07ba8f3ed |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-12T08:00:32Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-b8a8c9e0cc10421a860d41d07ba8f3ed2022-12-22T00:32:09ZengElsevierNeurobiology of Disease1095-953X2022-08-01170105771Immune-related biomarkers for Parkinson's diseaseIlham Y. Abdi0Simona S. Ghanem1Omar M. El-Agnaf2College of Health and Life Sciences, Hamad bin Khalifa University, Qatar Foundation, P.O. Box 34110, Doha, Qatar; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, P.O. Box 34110, Doha, QatarNeurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, P.O. Box 34110, Doha, QatarCollege of Health and Life Sciences, Hamad bin Khalifa University, Qatar Foundation, P.O. Box 34110, Doha, Qatar; Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, P.O. Box 34110, Doha, Qatar; Corresponding author at: College of Health and Life Sciences, Hamad bin Khalifa University, Qatar Foundation, P.O. Box 34110, Doha, Qatar.Despite the increasing number of studies on Parkinson's disease and it being the second most common neurodegenerative disorder in the world, no established diagnostic markers or disease modifying therapies are available. Understanding the mechanisms involved in its pathogenesis and identifying markers capable of diagnosing or tracking progression of PD is greatly needed. Among the several factors identified to be involved in Parkinson's disease, the immune system has had increasingly growing evidence that presents a fresh avenue to investigate the pathology of the disease. The involvement of the immune system in the pathology of Parkinson's disease has been linked to an interaction between the peripheral and central nervous system immune response. Whether this involvement is due to an immune response being a cause or consequence of Parkinson's disease pathology is still a matter of debate. Players investigated include cytokines, chemokines, and immune-cells found in both the central and peripheral immune system. Herein, we discuss advances in the current literature on these immune-related markers and their potential use as markers for Parkinson's disease diagnosis and progression.http://www.sciencedirect.com/science/article/pii/S0969996122001632Parkinson's diseaseImmune responseBiomarkersInflammation |
| spellingShingle | Ilham Y. Abdi Simona S. Ghanem Omar M. El-Agnaf Immune-related biomarkers for Parkinson's disease Neurobiology of Disease Parkinson's disease Immune response Biomarkers Inflammation |
| title | Immune-related biomarkers for Parkinson's disease |
| title_full | Immune-related biomarkers for Parkinson's disease |
| title_fullStr | Immune-related biomarkers for Parkinson's disease |
| title_full_unstemmed | Immune-related biomarkers for Parkinson's disease |
| title_short | Immune-related biomarkers for Parkinson's disease |
| title_sort | immune related biomarkers for parkinson s disease |
| topic | Parkinson's disease Immune response Biomarkers Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S0969996122001632 |
| work_keys_str_mv | AT ilhamyabdi immunerelatedbiomarkersforparkinsonsdisease AT simonasghanem immunerelatedbiomarkersforparkinsonsdisease AT omarmelagnaf immunerelatedbiomarkersforparkinsonsdisease |